澳大利亚斑点热群立克次体的蛋白质特性及霍氏立克次体的单克隆抗体分型
Protein characterization of Australian spotted fever group rickettsiae and monoclonal antibody typing of Rickettsia honei.
作者信息
Stenos J, Ross B, Feng H M, Crocquet-Valdes P, Walker D
机构信息
Victorian Infectious Diseases Reference Laboratory, Fairfield Hospital, Victoria, Australia.
出版信息
J Clin Microbiol. 1997 Jan;35(1):261-3. doi: 10.1128/jcm.35.1.261-263.1997.
Abstract
Rickettsial proteins rOmp A and rOmp B exist in both Rickettsia australis and Rickettsia honei but differ in molecular weight and antigenicity; in addition, they produce distinct immunogenic responses and appear to be to conformationally dependent antigens. Species-specific monoclonal antibodies for other spotted fever group rickettsial species did not react with R. honei. A PCR product of the repeat region of the rOmp A gene from R. honei was amplified and calculated to contain 11 repeat units.
摘要
澳大利亚立克次氏体和霍氏立克次氏体中均存在立克次氏体蛋白rOmp A和rOmp B，但它们的分子量和抗原性不同；此外，它们产生不同的免疫原性反应，似乎是构象依赖性抗原。针对其他斑点热群立克次氏体物种的种特异性单克隆抗体与霍氏立克次氏体不发生反应。扩增了霍氏立克次氏体rOmp A基因重复区域的PCR产物，经计算其含有11个重复单元。
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