Biology Department, Faculty of Science and Arts in Qilwah, Albaha University, Qilwah, Saudi Arabia.
Botany and Microbiology Department, Faculty of Science, Zagazig University, Zagazig, Egypt.
J Gastrointest Cancer. 2022 Sep;53(3):683-686. doi: 10.1007/s12029-021-00687-x. Epub 2021 Sep 1.
Pancreatic cancer is one of the malignant tumors in the digestive system all over the world. It has a very low survival rate. Although there is a great advancement in its therapy either through radiotherapy, chemotherapy, or other therapies, the overall survival is still less than 24 months. Another problem for pancreatic cancer is the resistance to its conventional chemotherapy (e.g., gemcitabine). From this point of view, there is an urgent need to find an effective drug treatment METHODS: The anticancer activity of the germinated fenugreek seed extract is examined in vitro and in vivo against BXPC-3 pancreatic cancer cell lines. Two groups of albino mice were injected with BXPC-3 cells: the first group remained non-treated and the second group was injected with IC50 of the fenugreek extract. The body weight and the survival rate were observed in the two groups and histological examination of the pancreatic tissue was observed RESULTS: Germinated fenugreek seed extract can be efficiently maximized the survival rate in pancreatic cancer mice and protect the pancreatic tissue from lesions related to cancer.
Germinated fenugreek seed extract can be used to fight pancreatic cancer.
胰腺癌是全球消化系统的恶性肿瘤之一，其生存率极低。尽管通过放疗、化疗或其他疗法在治疗方面取得了重大进展，但总体生存率仍不足 24 个月。胰腺癌的另一个问题是对常规化疗（如吉西他滨）的耐药性。从这个角度来看，迫切需要寻找有效的药物治疗方法。
体外和体内实验检测发芽胡芦巴种子提取物对 BXPC-3 胰腺癌细胞系的抗癌活性。两组白化小鼠被注射 BXPC-3 细胞：第一组未治疗，第二组注射胡芦巴提取物的 IC50。观察两组的体重和存活率，并观察胰腺组织的组织学检查。
发芽胡芦巴种子提取物可有效提高胰腺癌小鼠的存活率，并保护胰腺组织免受与癌症相关的损伤。
发芽胡芦巴种子提取物可用于治疗胰腺癌。
