Mohamed Hamza Elsayed Ahmed, Afridi Shakeeb, Khalil Ali Talha, Zohra Tanzeel, Alam Muhammad Masroor, Ikram Aamir, Shinwari Zabta Khan, Maaza Malik
UNESCO UNISA Africa Chair in Nanosciences and Nanotechnology, College of Graduate Studies, University of South Africa, Pretoria, South Africa.
NANOAFNET (Nanosciences African Network), Materials Research Department, iThemba LABS, Cape Town, South Africa.
AMB Express. 2019 Dec 12;9(1):200. doi: 10.1186/s13568-019-0923-1.
Biosynthesis of bismuth vanadate (BiVO) nanorods was performed using dried fruit extracts of Hyphaene thebaica as a cost effective reducing and stabilizing agent. XRD, DRS, FTIR, zeta potential, Raman, HR-SEM, HR-TEM, EDS and SAED were used to study the main physical properties while the biological properties were established by performing diverse assays. The zeta potential is reported as - 5.21 mV. FTIR indicated Bi-O and V-O vibrations at 640 cm and 700 cm/1120 cm. Characteristic Raman modes were observed at 166 cm, 325 cm and 787 cm. High resolution scanning and transmission electron micrographs revealed a rod like morphology of the BiVO. Bacillus subtilis, Klebsiella pneumonia, Fusarium solani indicated highest susceptibility to the different doses of BiVO nanorods. Significant protein kinase inhibition is reported for BiVO nanorods which suggests their potential anticancer properties. The nanorods revealed good DPPH free radical scavenging potential (48%) at 400 µg/mL while total antioxidant capacity of 59.8 µg AAE/mg was revealed at 400 µg/mL. No antiviral activity is reported on sabin like polio virus. Overall excellent biological properties are reported. We have shown that green synthesis can replace well established processes for synthesizing BiVO nanorods.
利用海枣的干果提取物作为一种经济高效的还原剂和稳定剂，进行了钒酸铋（BiVO）纳米棒的生物合成。采用X射线衍射（XRD）、漫反射光谱（DRS）、傅里叶变换红外光谱（FTIR）、zeta电位、拉曼光谱、高分辨率扫描电子显微镜（HR-SEM）、高分辨率透射电子显微镜（HR-TEM）、能谱分析（EDS）和选区电子衍射（SAED）研究其主要物理性质，同时通过多种测定确定其生物学性质。测得zeta电位为-5.21 mV。FTIR表明在640 cm和700 cm/1120 cm处有Bi-O和V-O振动。在166 cm、325 cm和787 cm处观察到特征拉曼模式。高分辨率扫描和透射电子显微镜图像显示BiVO呈棒状形态。枯草芽孢杆菌、肺炎克雷伯菌、茄类镰刀菌对不同剂量的BiVO纳米棒表现出最高敏感性。据报道，BiVO纳米棒具有显著的蛋白激酶抑制作用，这表明其具有潜在的抗癌特性。纳米棒在400 μg/mL时显示出良好的DPPH自由基清除潜力（48%），而在400 μg/mL时总抗氧化能力为59.8 μg AAE/mg。未报道对脊髓灰质炎病毒萨宾株样病毒有抗病毒活性。总体而言，其生物学性质优异。我们已经表明，绿色合成可以取代成熟的BiVO纳米棒合成方法。
