• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

会议报告和综述：下一代流感疫苗的免疫测定和保护相关性。

Meeting report and review: Immunological assays and correlates of protection for next-generation influenza vaccines.

机构信息

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

Division of Viral Products, Food and Drug Administration, Bethesda, MD, USA.

出版信息

Influenza Other Respir Viruses. 2020 Mar;14(2):237-243. doi: 10.1111/irv.12706. Epub 2019 Dec 13.

DOI:10.1111/irv.12706
PMID:31837101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7040967/
Abstract

BACKGROUND

This report summarizes the discussions and conclusions from the "Immunological Assays and Correlates of Protection for Next-Generation Influenza Vaccines" meeting which took place in Siena, Italy, from March 31, 2019, to April 2, 2019.

CONCLUSIONS

Furthermore, we review current correlates of protection against influenza virus infection and disease and their usefulness for the development of next generation broadly protective and universal influenza virus vaccines.

摘要

背景

本报告总结了于 2019 年 3 月 31 日至 4 月 2 日在意大利锡耶纳举行的“下一代流感疫苗的免疫测定和保护相关性”会议的讨论和结论。

结论

此外，我们回顾了目前针对流感病毒感染和疾病的保护相关性及其在开发新一代广泛保护和通用流感病毒疫苗方面的有用性。

相似文献

1
Meeting report and review: Immunological assays and correlates of protection for next-generation influenza vaccines.会议报告和综述：下一代流感疫苗的免疫测定和保护相关性。
Influenza Other Respir Viruses. 2020 Mar;14(2):237-243. doi: 10.1111/irv.12706. Epub 2019 Dec 13.
2
Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for Protection in a Serum Transfer Mouse Challenge Model.人血清中流感病毒血凝素茎特异性抗体是血清转移小鼠攻毒模型中保护作用的替代标志物。
mBio. 2017 Sep 19;8(5):e01463-17. doi: 10.1128/mBio.01463-17.
3
Inactivated H7 Influenza Virus Vaccines Protect Mice despite Inducing Only Low Levels of Neutralizing Antibodies.灭活H7流感病毒疫苗尽管仅诱导产生低水平的中和抗体，但仍可保护小鼠。
J Virol. 2017 Sep 27;91(20). doi: 10.1128/JVI.01202-17. Print 2017 Oct 15.
4
Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged with Pandemic H1N1 Virus.一种候选通用流感疫苗的气溶胶递送可降低感染大流行性H1N1病毒的猪的病毒载量。
J Immunol. 2016 Jun 15;196(12):5014-23. doi: 10.4049/jimmunol.1502632. Epub 2016 May 6.
5
A Bivalent Heterologous DNA Virus-Like-Particle Prime-Boost Vaccine Elicits Broad Protection against both Group 1 and 2 Influenza A Viruses.一种二价异源DNA病毒样颗粒初免-加强疫苗可引发针对1型和2型甲型流感病毒的广泛保护。
J Virol. 2017 Apr 13;91(9). doi: 10.1128/JVI.02052-16. Print 2017 May 1.
6
Universal Influenza Virus Vaccines That Target the Conserved Hemagglutinin Stalk and Conserved Sites in the Head Domain.针对保守的血凝素茎和头部结构域保守位点的通用流感病毒疫苗。
J Infect Dis. 2019 Apr 8;219(Suppl_1):S62-S67. doi: 10.1093/infdis/jiy711.
7
Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting Serological Breadth.新型 H3 特异性广谱中和单克隆抗体的鉴定 该抗体靶向血凝素球状头部，来源于一位具有广泛血清学反应性的流感病毒免疫供者
J Virol. 2020 Feb 28;94(6). doi: 10.1128/JVI.01035-19.
8
Impact of pre-existing immunity on the induction of functional cross-reactive anti-hemagglutinin stalk antibodies following vaccination with an AS03 adjuvanted pandemic H1N1 vaccine.AS03 佐剂季节性流感 H1N1 疫苗接种后，预先存在的免疫对功能性交叉反应性抗血凝素茎抗体诱导的影响。
Vaccine. 2018 Apr 12;36(16):2213-2219. doi: 10.1016/j.vaccine.2018.02.022. Epub 2018 Mar 13.
9
Implications of broadly neutralizing antibodies in the development of a universal influenza vaccine.广泛中和抗体在通用流感疫苗研发中的意义。
Curr Opin Virol. 2016 Apr;17:110-115. doi: 10.1016/j.coviro.2016.03.002. Epub 2016 Mar 28.
10
Vaccination with Recombinant Parainfluenza Virus 5 Expressing Neuraminidase Protects against Homologous and Heterologous Influenza Virus Challenge.接种表达神经氨酸酶的重组副流感病毒5可抵御同源和异源流感病毒攻击。
J Virol. 2017 Nov 14;91(23). doi: 10.1128/JVI.01579-17. Print 2017 Dec 1.

引用本文的文献

1
First Among Equals: The Case for High-quality Clinical Data in Influenza Vaccines.平等中的首要地位：流感疫苗高质量临床数据的理由
Clin Infect Dis. 2025 Aug 1;81(1):7-9. doi: 10.1093/cid/ciaf290.
2
Neutralizing antibody levels as a key factor in determining the immunogenic efficacy of the novel PEDV alpha coronavirus vaccine.中和抗体水平是决定新型猪流行性腹泻病毒α冠状病毒疫苗免疫原性效力的关键因素。
Vet Q. 2025 Dec;45(1):1-20. doi: 10.1080/01652176.2025.2509506. Epub 2025 May 28.
3
Evaluating Hemagglutination Inhibition Antibody Titers as a Correlate of Protection for Influenza: A Sensitivity Analysis Based on Information Theory and Causal Inference.评估血凝抑制抗体滴度作为流感保护相关性指标：基于信息论和因果推断的敏感性分析
J Glob Infect Dis. 2025 Feb 24;17(1):17-23. doi: 10.4103/jgid.jgid_89_24. eCollection 2025 Jan-Mar.
4
Catch, Cut, or Block? Versatile 4-N-Derivatized Sialyl Glycosides for Influenza Virus Neuraminidase Detection and Purification.捕获、切割还是阻断？用于流感病毒神经氨酸酶检测与纯化的多功能4-N-衍生化唾液酸糖苷
Angew Chem Int Ed Engl. 2025 Jun 17;64(25):e202505903. doi: 10.1002/anie.202505903. Epub 2025 Apr 21.
5
An mRNA-based seasonal influenza vaccine in adults: Results of two phase 3 randomized clinical trials and correlate of protection analysis of hemagglutination inhibition titers.一种用于成人的基于信使核糖核酸的季节性流感疫苗：两项3期随机临床试验结果及血凝抑制滴度的保护相关性分析
Hum Vaccin Immunother. 2025 Dec;21(1):2484088. doi: 10.1080/21645515.2025.2484088. Epub 2025 Apr 2.
6
Highly pathogenic avian influenza H5N1: history, current situation, and outlook.高致病性禽流感H5N1：历史、现状与展望
J Virol. 2025 Apr 15;99(4):e0220924. doi: 10.1128/jvi.02209-24. Epub 2025 Mar 27.
7
Systems immunology analysis of human immune organoids identifies host-specific correlates of protection to different influenza vaccines.对人类免疫类器官的系统免疫学分析确定了针对不同流感疫苗的宿主特异性保护相关性。
Cell Stem Cell. 2025 Apr 3;32(4):529-546.e6. doi: 10.1016/j.stem.2025.01.014. Epub 2025 Feb 21.
8
Truncated NS1 Influenza A Virus Induces a Robust Antigen-Specific Tissue-Resident T-Cell Response and Promotes Inducible Bronchus-Associated Lymphoid Tissue Formation in Mice.截短的甲型流感病毒NS1诱导强烈的抗原特异性组织驻留T细胞反应并促进小鼠诱导性支气管相关淋巴组织形成。
Vaccines (Basel). 2025 Jan 10;13(1):58. doi: 10.3390/vaccines13010058.
9
Targets of influenza human T-cell response are mostly conserved in H5N1.甲型流感病毒H5N1亚型中人类T细胞应答的靶点大多是保守的。
mBio. 2025 Feb 5;16(2):e0347924. doi: 10.1128/mbio.03479-24. Epub 2024 Dec 23.
10
Estimating Standard-Dose and High-Dose Fluzone Vaccine Efficacies for Influenza A Based on Hemagglutination Inhibition Titers.基于血凝抑制效价估算甲型流感标准剂量和高剂量流感裂解疫苗的效力
J Infect Dis. 2025 Jun 2;231(5):1336-1345. doi: 10.1093/infdis/jiae615.

本文引用的文献

1
Moving from Empirical to Rational Vaccine Design in the 'Omics' Era.“组学”时代从经验性疫苗设计迈向理性疫苗设计
Vaccines (Basel). 2019 Aug 14;7(3):89. doi: 10.3390/vaccines7030089.
2
Convening on the influenza human viral challenge model for universal influenza vaccines, Part 2: Methodologic considerations.召集人感染流感病毒的挑战模型通用流感疫苗，第 2 部分：方法学的考虑。
Vaccine. 2019 Aug 14;37(35):4830-4834. doi: 10.1016/j.vaccine.2019.06.053.
3
Meeting report: Convening on the influenza human viral challenge model for universal influenza vaccines, Part 1: Value; challenge virus selection; regulatory, industry and ethical considerations; increasing standardization, access and capacity.会议报告：召开通用流感疫苗的流感人类病毒挑战模型会议，第 1 部分：价值；挑战病毒选择；监管、行业和伦理考虑因素；提高标准化、可及性和能力。
Vaccine. 2019 Aug 14;37(35):4823-4829. doi: 10.1016/j.vaccine.2019.06.080.
4
Pre-existing Antineuraminidase Antibodies Are Associated With Shortened Duration of Influenza A(H1N1)pdm Virus Shedding and Illness in Naturally Infected Adults.预先存在的抗神经氨酸酶抗体与自然感染成年人甲型 H1N1 流感病毒脱落和疾病持续时间缩短相关。
Clin Infect Dis. 2020 May 23;70(11):2290-2297. doi: 10.1093/cid/ciz639.
5
Pseudotype Neutralization Assays: From Laboratory Bench to Data Analysis.假型中和试验：从实验室台面到数据分析
Methods Protoc. 2018 Jan 22;1(1):8. doi: 10.3390/mps1010008.
6
Novel correlates of protection against pandemic H1N1 influenza A virus infection.新型大流行性 H1N1 流感 A 病毒感染保护相关因素。
Nat Med. 2019 Jun;25(6):962-967. doi: 10.1038/s41591-019-0463-x. Epub 2019 Jun 3.
7
The human antibody response to influenza A virus infection and vaccination.人体对甲型流感病毒感染和疫苗接种的抗体反应。
Nat Rev Immunol. 2019 Jun;19(6):383-397. doi: 10.1038/s41577-019-0143-6.
8
Protein Microarray Analysis of the Specificity and Cross-Reactivity of Influenza Virus Hemagglutinin-Specific Antibodies.蛋白质微阵列分析流感病毒血凝素特异性抗体的特异性和交叉反应性。
mSphere. 2018 Dec 12;3(6):e00592-18. doi: 10.1128/mSphere.00592-18.
9
Moving Forward: Recent Developments for the Ferret Biomedical Research Model.向前推进：雪貂生物医学研究模型的最新进展。
mBio. 2018 Jul 17;9(4):e01113-18. doi: 10.1128/mBio.01113-18.
10
Immune History and Influenza Vaccine Effectiveness.免疫史与流感疫苗效力
Vaccines (Basel). 2018 May 21;6(2):28. doi: 10.3390/vaccines6020028.