Nutraceuticals Research Program, School of Biomedical Sciences and Pharmacy.
School of Medicine and Public Health.
Nutr Rev. 2020 Jul 1;78(7):563-578. doi: 10.1093/nutrit/nuz073.
Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs) are widely considered as nootropic agents that may be beneficial in reversing cognitive impairment.
The present systematic review of randomized controlled trials was conducted to determine the changes in cognitive function after intervention with LCn-3PUFA supplementation in non-demented adults, including those with mild cognitive impairment.
Five databases (MEDLINE, CINAHL, Scopus, EMBASE, and the Cochrane Library) were searched systematically along with reference lists of selected articles.
Studies were eligible for inclusion if they measured the effect of LCn-3PUFA supplementation on cognition in non-demented adults.
A total of 787 records were screened, of which 25 studies were eligible for inclusion. Treatment effects were summarized as global cognitive function for primary outcome and measured using the Mini-Mental State Examination and individual cognitive domains for secondary outcome. The pooled effect sizes were estimated using Hedge's g and random-effects modeling.
Results from randomized controlled trials indicate that LCn-3PUFAs have no effect on global cognitive function (Hedge's g = 0.02; 95% confidence interval, -0.12 to 0.154), and among the specific cognitive domains, only memory function showed a mild benefit (Hedge's g = 0.31; P = 0.003; z = 2.945).
The existing literature suggests that LCn-3PUFA supplementation could provide a mild benefit in improving memory function in non-demented older adults.
PROSPERO registration no. CRD42017078664.
长链ω-3 多不饱和脂肪酸（LCn-3PUFA）被广泛认为是具有神经保护作用的益智药，可能有益于逆转认知障碍。
本系统评价旨在评估非痴呆成年人（包括轻度认知障碍者）接受 LCn-3PUFA 补充干预后认知功能的变化。
系统检索了 5 个数据库（MEDLINE、CINAHL、Scopus、EMBASE 和 Cochrane Library），并查阅了选定文章的参考文献列表。
如果研究测量了 LCn-3PUFA 补充对非痴呆成年人认知的影响，则符合纳入标准。
共筛选了 787 篇记录，其中 25 项研究符合纳入标准。主要结局为总体认知功能，采用简易精神状态检查（Mini-Mental State Examination）进行测量；次要结局为个体认知域。使用 Hedge's g 和随机效应模型汇总治疗效果。
随机对照试验的结果表明，LCn-3PUFA 对总体认知功能无影响（Hedge's g = 0.02；95%置信区间，-0.12 至 0.154），在特定认知域中，只有记忆功能显示出轻微的获益（Hedge's g = 0.31；P = 0.003；z = 2.945）。
现有文献表明，LCn-3PUFA 补充可能对改善非痴呆老年人大脑的记忆功能有益。
PROSPERO 注册号 CRD42017078664。
Zotero 插件