Richters A
University of Southern California, School of Medicine, Department of Pathology, Los Angeles 90033.
J Toxicol Environ Health. 1988;25(3):383-90. doi: 10.1080/15287398809531217.
In this article we report inhalation effects of nitrogen dioxide (NO2) and ozone (O3) mixture as well as O3 alone on blood-borne cancer cell colonization of lungs. The findings are discussed in light of our earlier studies with NO2 exposure alone. In all of these studies the mouse B16 melanoma model was used. Animals were exposed to ambient concentrations of pollutants before melanoma-cell infusion. The results have indicated that inhalation of NO2 played a significant role in facilitation of blood-borne cancer cell spread, while O3 inhalation did not. With respect to mechanisms involved, the role of natural immunity was investigated and its was postulated that nitrogen dioxide may affect cells of the immune system and may in part account for the results. These findings may have direct bearing on dissemination of human cancer cells, since many cancer patients have circulating cancer cells and are exposed daily to noxious air pollutants. Most importantly, this effect may be preventable by reducing air pollution in urban areas.
在本文中，我们报告了二氧化氮（NO₂）和臭氧（O₃）混合物以及单独的O₃对肺血行癌细胞定植的吸入效应。结合我们早期单独暴露于NO₂的研究对这些发现进行了讨论。在所有这些研究中，均使用了小鼠B16黑色素瘤模型。在注入黑色素瘤细胞之前，将动物暴露于环境浓度的污染物中。结果表明，吸入NO₂在促进血行癌细胞扩散方面发挥了重要作用，而吸入O₃则没有。关于其中涉及的机制，对天然免疫的作用进行了研究，并推测二氧化氮可能影响免疫系统细胞，这可能部分解释了实验结果。这些发现可能与人类癌细胞的扩散直接相关，因为许多癌症患者体内都有循环癌细胞，并且每天都暴露于有害空气污染物中。最重要的是，通过减少城市地区的空气污染，这种效应可能是可以预防的。
