Richters A
J Surg Oncol. 1981;17(2):159-62. doi: 10.1002/jso.2930170210.
An experimental model was designed to test the possibility that inhalation of a noxious air pollutant may facilitate the blood-borne cancer cell metastasis to the lungs. Animals were exposed to inhalation of air containing 0.8 ppm of nitrogen dioxide for 12 weeks. After this period, animals were infused intravenously with melanoma cells, and 3 weeks later lungs were examined for metastases. The results indicate that NO2exposed animals develop significantly higher number of lung metastases (P less than 0.0025) than the controls. Such results raise the possibility that the inhalation of NO2 from ambient air may facilitate the seeding and proliferation of blood-borne cancer cells in the human lung.
设计了一个实验模型来测试吸入有害空气污染物是否会促进血行癌细胞转移至肺部。将动物暴露于吸入含0.8 ppm二氧化氮的空气环境中12周。在此期间过后，给动物静脉注射黑色素瘤细胞，3周后检查肺部是否有转移瘤。结果表明，与对照组相比，暴露于二氧化氮环境中的动物发生肺转移瘤的数量显著更多（P小于0.0025）。这些结果增加了一种可能性，即从环境空气中吸入二氧化氮可能会促进血行癌细胞在人肺中的着床和增殖。
