Department of Community Medicine, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Ministry of Health, Jeddah, Saudi Arabia.
J Infect Public Health. 2020 May;13(5):692-696. doi: 10.1016/j.jiph.2019.11.016. Epub 2019 Dec 13.
MERS-coronavirus infection is currently responsible for considerable morbidity and mortality in Saudi Arabia. Understanding its burden, as an emerging infectious disease, is vital for devising appropriate control strategies. In this study, the burden of MERS-CoV was estimated over 31months period from June 6, 2012 to January 5, 2015. The total number of patients was 835; 528 (63.2%) patients were male, 771 (92.3%) patients were ≥25 years of age, and 210 (25.1%) patients were healthcare workers. A total of 751 (89.9%) patients required hospitalization. The median duration between onset of illness and hospitalization was 2 days (interquartile range, 0-5). The median length of hospital stay was 14 days (IQR, 6-27). The overall case fatality rate was 43.1%. Basic reproductive number was 0.9. Being Saudi, non-healthcare workers, and age ≥65 years were significantly associated with higher mortality. In conclusion, MERS-CoV infection caused a substantial health burden in Saudi Arabia.
中东呼吸综合征冠状病毒感染目前在沙特阿拉伯造成相当大的发病率和死亡率。了解其作为一种新发传染病的负担对于制定适当的控制策略至关重要。在这项研究中，估计了 2012 年 6 月 6 日至 2015 年 1 月 5 日期间 31 个月期间的 MERS-CoV 负担。共有 835 名患者；528 名（63.2%）患者为男性，771 名（92.3%）患者年龄≥25 岁，210 名（25.1%）患者为医护人员。共有 751 名（89.9%）患者需要住院治疗。发病和住院之间的中位时间为 2 天（四分位距，0-5）。住院中位时间为 14 天（IQR，6-27）。总病死率为 43.1%。基本繁殖数为 0.9。沙特人、非医护人员和年龄≥65 岁与更高的死亡率显著相关。总之，MERS-CoV 感染在沙特阿拉伯造成了相当大的健康负担。
