Garout Mohammed A, Jokhdar Hani A A, Aljahdali Imad A, Zein Ahmed R, Goweda Reda A, Hassan-Hussein Abdurahman
Department of Community Medicine, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
Intensive Care Department, King Fahad Hospital, Jeddah, Kingdom of Saudi Arabia.
Cent Eur J Public Health. 2018 Jun;26(2):87-91. doi: 10.21101/cejph.a4764.
The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a novel coronavirus circulating in the Arabian Peninsula since September 2012. It leads to significant respiratory disease and among patients with co-morbidities is associated with high mortality. This research studied the mortality rate of MERS-CoV among intensive care unit (ICU) patients and the correlation of mortality with different co-morbidities.
This was a retrospective observational study conducted at the Intensive Care Unit of the King Fahad Hospital, Jeddah, Saudi Arabia. Data was obtained through patient chart review.
The total sample consisted of 52 laboratory-confirmed MERS-CoV infection patients. 39 patients died, with a 75% case-fatality rate. Many patients had underlying co-morbidities, including diabetes mellitus (51.9%), hypertension (46.2%), and chronic renal disease (21.2%).
MERS-CoV ICU mortality remains markedly high due to a combination of factors; the disease process of MERS-CoV leads to multiple organ failure, particularly respiratory and renal failure.
中东呼吸综合征冠状病毒（MERS-CoV）是一种自2012年9月起在阿拉伯半岛传播的新型冠状病毒。它会引发严重的呼吸系统疾病，在患有合并症的患者中死亡率很高。本研究调查了重症监护病房（ICU）中MERS-CoV患者的死亡率以及死亡率与不同合并症之间的相关性。
这是一项在沙特阿拉伯吉达法赫德国王医院重症监护病房进行的回顾性观察研究。数据通过查阅患者病历获得。
总样本包括52例实验室确诊的MERS-CoV感染患者。39例患者死亡，病死率为75%。许多患者有潜在的合并症，包括糖尿病（51.9%）、高血压（46.2%）和慢性肾病（21.2%）。
由于多种因素的综合作用，MERS-CoV在ICU中的死亡率仍然显著较高；MERS-CoV的疾病进程会导致多器官功能衰竭，尤其是呼吸和肾衰竭。
