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头皮皮肤多形性肉瘤——两例报告

Dermal Pleomorphic Sarcoma of the Scalp - Report of Two Cases.

作者信息

Wollina Uwe, Schönlebe Jacqueline, Bujok Violetta, Lotti Torello, Tchernev Georgi, Temelkova Ivanka, Vojvodic Aleksandra

机构信息

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany.

Institute of Pathology "Georg Schmorl", Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany.

出版信息

Open Access Maced J Med Sci. 2019 May 30;7(18):2982-2984. doi: 10.3889/oamjms.2019.274. eCollection 2019 Sep 30.

DOI:10.3889/oamjms.2019.274
PMID:31850104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6910786/
Abstract

BACKGROUND

Neoplasias of the UV-exposed head-and-neck area of the elderly include non-melanoma skin cancers of various origin.

CASE REPORT

We report two cases of rapid growing exophytic scalp tumors on chronic sun-damaged skin, in one case with a tendency of bleeding. The tumours were removed by wide surgical excision with 3D margin control, and the resulting defect was covered by a meshed split skin graft. Histopathologic examination disclosed a dermal pleomorphic sarcoma in both cases. The staging was unremarkable in both patients.

CONCLUSIONS

Sarcomatous tumours of the scalp should be completely excised with a 3D margin control. Dermal pleomorphic sarcoma is a more aggressive variant compared to atypical fibroxanthoma despite some similarities.

摘要

背景

老年人紫外线暴露的头颈部区域的肿瘤包括各种起源的非黑色素瘤皮肤癌。

病例报告

我们报告了两例发生在长期日晒损伤皮肤上的快速生长的外生性头皮肿瘤,其中一例有出血倾向。肿瘤通过三维切缘控制的广泛手术切除, resulting defect was covered by a meshed split skin graft。组织病理学检查显示两例均为真皮多形性肉瘤。两名患者的分期均无异常。

结论

头皮肉瘤性肿瘤应通过三维切缘控制完全切除。尽管有一些相似之处,但与非典型纤维黄色瘤相比,真皮多形性肉瘤是一种更具侵袭性的变体。

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本文引用的文献

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Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype.非典型性纤维黄色瘤和多形性皮肤肉瘤的全基因组甲基化谱分析及拷贝数分析显示出相似的分子表型。
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头皮缺损采用头皮与下肢取皮行部分厚度皮片移植的比较结果:一项临床试验研究
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Conception and Management of a Poorly Understood Spectrum of Dermatologic Neoplasms: Atypical Fibroxanthoma, Pleomorphic Dermal Sarcoma, and Undifferentiated Pleomorphic Sarcoma.对一类理解不足的皮肤肿瘤谱系的概念与管理:非典型纤维黄色瘤、多形性真皮肉瘤和未分化多形性肉瘤
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Atypical Fibroxanthoma Revisited.再探非典型纤维黄色瘤
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Pleomorphic dermal sarcoma: a more aggressive neoplasm than previously estimated.多形性皮肤肉瘤:一种比先前估计更具侵袭性的肿瘤。
J Cutan Pathol. 2016 Feb;43(2):101-12. doi: 10.1111/cup.12603. Epub 2015 Sep 29.
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Atypical fibroxanthoma: a series of 56 tumors and an unexplained uneven distribution of cases in southeast Germany.非典型性纤维黄色瘤:56例肿瘤病例及德国东南部病例分布不均的原因不明分析
Head Neck. 2015 Jun;37(6):829-34. doi: 10.1002/hed.23673. Epub 2014 Jun 20.
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Sarcoma-like tumor of head and neck skin.头颈部皮肤肉瘤样肿瘤。
Am J Surg Pathol. 2014 Jul;38(7):956-65. doi: 10.1097/PAS.0000000000000210.
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Pleomorphic dermal sarcoma: adverse histologic features predict aggressive behavior and allow distinction from atypical fibroxanthoma.多形性皮肤肉瘤:不良组织学特征预示侵袭性行为,并可与非典型纤维黄色瘤相区别。
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