Seretis Konstantinos, Klaroudas Antonios, Galani Vasiliki, Papathanakos Georgios, Varouktsi Anna, Mitselou Antigoni, Batistatou Anna, Lampri Evangeli
Department of Plastic Surgery, Medical School University of Ioannina, Greece.
Department of Anatomy-Histology-Embryology, School of Medicine University of Ioannina, Greece.
J Surg Case Rep. 2023 Aug 4;2023(8):rjad374. doi: 10.1093/jscr/rjad374. eCollection 2023 Aug.
Pleomorphic dermal sarcoma (PDS) is a rare mesenchymal tissue tumor. Its differential diagnosis from similar tumors, such as low differentiated squamous cell carcinoma, fibrosarcoma, desmoplastic melanoma, atypical fibroxanthoma (AFX), may be difficult, as they have similar clinical and histological presentation. We present a case of an 83-year-old man exhibiting an exophytic scalp lesion. Excision of the lesion was performed, ensuring clear surgical margins and pathologic examination revealed an invasive pleomorphic dermal sarcoma. This case highlights a rare case of a large pleomorphic dermal sarcoma, and it discusses the histological, molecular features, its differential diagnosis and management of PDS.
多形性皮肤肉瘤（PDS）是一种罕见的间叶组织肿瘤。它与类似肿瘤的鉴别诊断可能具有挑战性，比如低分化鳞状细胞癌、纤维肉瘤、促纤维增生性黑色素瘤、非典型纤维黄色瘤（AFX），因为它们具有相似的临床和组织学表现。我们报告一例83岁男性患者，其头皮出现外生性病变。对该病变进行了切除，确保手术切缘清晰，病理检查显示为浸润性多形性皮肤肉瘤。本病例突出了一例罕见的大型多形性皮肤肉瘤，并讨论了多形性皮肤肉瘤的组织学、分子特征、鉴别诊断及治疗。
