Lu Wei, Cao Fenghua, Wang Shengjun, Sheng Xiumei, Ma Jie
Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Zhenjiang Hospital of Chinese Traditional and Western Medicine, Zhenjiang, China.
Front Oncol. 2019 Nov 26;9:1099. doi: 10.3389/fonc.2019.01099. eCollection 2019.
Metabolism is a complex network of regulatory system. Cells often alter their metabolism in response to the changes in their environment. These adaptive changes are particularly pronounced in tumor cells, known as metabolic reprogramming. Metabolic reprogramming is considered to be one of the top 10 characteristics of tumor cells. Glucose and lipid metabolism are important components of metabolic reprogramming. A large number of experimental studies have shown that long non-coding RNAs (lncRNAs) play an important role in glucose and lipid metabolism. The current review briefly introduces the regulatory effect of lncRNAs on glucose and lipid metabolism of tumor cells, and the significance of lncRNA-mediated metabolism in tumor therapy, hoping to provide new strategies for clinical targeting tumor therapy.
新陈代谢是一个复杂的调节系统网络。细胞常常会根据其环境变化来改变自身的新陈代谢。这些适应性变化在肿瘤细胞中尤为显著，被称为代谢重编程。代谢重编程被认为是肿瘤细胞的十大特征之一。葡萄糖和脂质代谢是代谢重编程的重要组成部分。大量实验研究表明，长链非编码RNA（lncRNA）在葡萄糖和脂质代谢中发挥着重要作用。本综述简要介绍了lncRNA对肿瘤细胞葡萄糖和脂质代谢的调节作用，以及lncRNA介导的代谢在肿瘤治疗中的意义，希望能为临床靶向肿瘤治疗提供新策略。
