Guo Yuhong, Lv Bin, Liu Renfeng, Dai Zhengzai, Zhang Feifei, Liang Yiping, Yu Bo, Zeng Duo, Lv Xiao-Bin, Zhang Zhiping
Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, Northern 128 Xiangshan Road, Nanchang, 330008, Jiangxi, People's Republic of China.
Department of Orthopedics, The Third Affiliated Hospital of Nanchang University, Northern 128 Xiangshan Road, Nanchang, 330008, Jiangxi, People's Republic of China.
Cancer Cell Int. 2021 Apr 13;21(1):209. doi: 10.1186/s12935-021-01926-8.
The metabolic change of tumor cells is an extremely complicated process that involves the intersection and integration of various signal pathways. Compared with normal tissues, cancer cells show distinguished metabolic characteristics called metabolic reprogramming, which has been considered as a sign of cancer occurrence. With the deepening of tumor research in recent years, people gradually found that amino acid metabolism played crucial roles in cancer progression. Long non-coding RNAs (lncRNAs), which are implicated in many important biological processes, were firstly discovered dysregulating in cancer tissues and participating in extensive regulation of tumorigenesis. This review focuses on the reprogramming of amino acid metabolism in cancers and how lncRNAs participate in the regulatory network by interacting with other macromolecular substances. Understanding the functions of lncRNA in amino acid reprogramming in tumors might provide a new vision on the mechanisms of tumorigenesis and the development of new approaches for cancer therapy.
肿瘤细胞的代谢变化是一个极其复杂的过程，涉及各种信号通路的交叉和整合。与正常组织相比，癌细胞表现出独特的代谢特征，即代谢重编程，这被认为是癌症发生的标志。近年来，随着肿瘤研究的深入，人们逐渐发现氨基酸代谢在癌症进展中起着关键作用。长链非编码RNA（lncRNAs）参与许多重要的生物学过程，最初被发现其在癌组织中表达失调，并参与肿瘤发生的广泛调控。本综述重点关注癌症中氨基酸代谢的重编程，以及lncRNAs如何通过与其他大分子物质相互作用参与调控网络。了解lncRNA在肿瘤氨基酸重编程中的功能，可能为肿瘤发生机制提供新的视角，并为癌症治疗新方法的开发提供思路。
