海湾战争综合症相关的白细胞介素6和C反应蛋白血液水平升高：炎症的生物标志物证据。
Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammation.
作者信息
Butterick Tammy A, Trembley Janeen H, Hocum Stone Laura L, Muller Clemma J, Rudquist Rebecca R, Bach Ronald R
机构信息
Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA.
Department of Food Science and Nutrition, University of Minnesota, St Paul, MN, USA.
出版信息
BMC Res Notes. 2019 Dec 18;12(1):816. doi: 10.1186/s13104-019-4855-2.
OBJECTIVE
Gulf War Illness is a chronic multisymptom disorder severely impacting the health and well-being of many Veterans of the 1990-1991 Gulf War. Symptoms that define the disease include pain, fatigue, mood and memory impairments, gastrointestinal problems, lung disorders, and skin rashes. In our previous biomarker study, we discovered Gulf War Illness-associated proinflammatory blood biomarkers. Therefore, we hypothesized that chronic inflammation causes the symptoms that define this disorder. Testing the chronic inflammation hypothesis is the objective of this study.
RESULTS
The biomarker fingerprint of Gulf War Illness is the end-product of a cascade of proinflammatory cytokine signals. In particular, the observed increase in C-reactive protein predicts a corresponding increase in interleukin 6, the cytokine that stimulates hepatocytes to produce C-reactive protein. Therefore, in this study we measured potential upstream cytokine signals in plasma samples from Gulf War Veterans. As predicted, a positive correlation between interleukin 6 and C-reactive protein was observed.
目的
海湾战争综合征是一种慢性多症状疾病，严重影响了许多1990 - 1991年海湾战争退伍军人的健康和幸福。该疾病的症状包括疼痛、疲劳、情绪和记忆障碍、胃肠道问题、肺部疾病和皮疹。在我们之前的生物标志物研究中，我们发现了与海湾战争综合征相关的促炎血液生物标志物。因此，我们推测慢性炎症导致了定义该疾病的症状。本研究的目的是检验慢性炎症假说。
结果
海湾战争综合征的生物标志物特征是一系列促炎细胞因子信号的终产物。特别是，观察到的C反应蛋白增加预示着白细胞介素6相应增加，白细胞介素6是刺激肝细胞产生C反应蛋白的细胞因子。因此，在本研究中，我们测量了海湾战争退伍军人血浆样本中潜在的上游细胞因子信号。正如预测的那样，观察到白细胞介素6和C反应蛋白之间存在正相关。
Zotero 插件