J Assoc Nurses AIDS Care. 2020 Mar-Apr;31(2):241-248. doi: 10.1097/JNC.0000000000000144.
Approximately one third of patients coinfected with HIV and hepatitis C virus (HCV) who initiate direct-acting antivirals (DAAs) for HCV treatment may have to switch antiretroviral therapy (ART) because of drug interactions. ART switches can negatively affect quality of life, increase HIV symptom burden, and delay HCV therapy. Approaches to identify ART/DAA drug interactions that minimize the impact of switching ART are urgently needed. Nurses can lead the way in addressing this new and major need. We provide a guide for registered nurses and nurse practitioners who care for patients coinfected with HIV and HCV to identify HIV/HCV drug interactions and manage ART/DAA coadministration when needed.
约三分之一同时感染艾滋病毒和丙型肝炎病毒 (HCV) 的患者在开始接受直接作用抗病毒药物 (DAA) 治疗 HCV 时，可能由于药物相互作用而不得不更换抗逆转录病毒治疗 (ART)。ART 转换会对生活质量产生负面影响，增加 HIV 症状负担，并延迟 HCV 治疗。因此，迫切需要寻找识别 ART/DAA 药物相互作用的方法，以最大程度地减少更换 ART 的影响。护士可以在解决这一新的重大需求方面发挥主导作用。我们为护理同时感染 HIV 和 HCV 的患者的注册护士和执业护士提供了一份指南，以帮助他们识别 HIV/HCV 药物相互作用，并在需要时管理 ART/DAA 联合用药。
