改变交感神经功能的药物对离体大鼠尾动脉对依替福林和酪胺反应的影响。

The effects of agents modifying sympathetic nerve function on the response of the isolated rat tail artery to etilefrine and tyramine.

作者信息

Frost B R, Frewin D B, Gerke D C, Downey J A

出版信息

Aust J Exp Biol Med Sci. 1978 Aug;56(4):499-505. doi: 10.1038/icb.1978.56.

DOI:10.1038/icb.1978.56

Abstract

The effects of etilefrine on the ventral caudal artery of the rat have been examined in the presence of agents modifying sympathetic nerve function. Catecholamine levels were also measured in adjacent segments of artery to those studied pharmacologically and an attempt made to relate vascular response to etilefrine (and tyramine) with catecholamine content. Both guanethidine and reserpine produced significant attenuation of the vascular effects of etilefrine and tyramine. Pre-treatment with a monoamine oxidase inhibitor caused an increase in tissue catecholamine levels but, paradoxically, depressed the vascular response to etilefrine. The significance of some of the findings in terms of an indirect component to etilefrine's action are discussed.

摘要

在使用改变交感神经功能的药物的情况下，研究了乙基肾上腺素对大鼠尾腹侧动脉的作用。还测量了与药理学研究的动脉相邻节段中的儿茶酚胺水平，并尝试将对乙基肾上腺素（和酪胺）的血管反应与儿茶酚胺含量联系起来。胍乙啶和利血平均显著减弱了乙基肾上腺素和酪胺的血管效应。用单胺氧化酶抑制剂预处理会导致组织儿茶酚胺水平升高，但矛盾的是，会降低对乙基肾上腺素的血管反应。讨论了一些发现对于乙基肾上腺素作用的间接成分的意义。