依替福林的血管效应。进一步研究以证实该药物主要的间接拟交感神经作用。

Vascular effects of etilefrine. Further studies to substantiate the predominant indirect sympathomimetic action of this agent.

作者信息

Frost B R, Frewin D B, Downey J A

出版信息

Aust J Exp Biol Med Sci. 1979 Aug;57(4):443-6. doi: 10.1038/icb.1979.44.

DOI:10.1038/icb.1979.44

Abstract

The suggested use of etilefrine in the treatment of patients with orthostatic hypotension is based on the premise that it has an action similar to that of noradrenaline (Miller, Wiener and Bloomfield, 1973). However, earlier work from this laboratory (Frost, Frewin and Gerke, 1977; Frost, Frewin, Gerke and Downey, 1978; Frost, Halloran, Frewin, Gerke and Downey, 1978) on blood vessels in the rat tail has suggested that the drug acts predominantly as an indirect sympathomimetic agent. The present study examined the action of etilefrine on the central artery of the rabbit ear. This vessel is known to have a rich sympathetic innervation (de la Lande, Frewin and Waterson, 1967) and has the added advantage that it can be surgically denervated. It therefore became possible to examine the effects of etilefrine on both normal and denervated arteries and to quantitate the extent to which the drug relied on the symphathetic nerves for its vasoconstrictor effects.

摘要

有人建议使用乙基肾上腺素治疗体位性低血压患者，其依据是该药物具有与去甲肾上腺素相似的作用（米勒、维纳和布卢姆菲尔德，1973年）。然而，该实验室早期的研究工作（弗罗斯特、弗鲁因和格克，1977年；弗罗斯特、弗鲁因、格克和唐尼，1978年；弗罗斯特、哈洛伦、弗鲁因、格克和唐尼，1978年）针对大鼠尾部血管的研究表明，该药物主要作为一种间接拟交感神经药起作用。本研究检测了乙基肾上腺素对兔耳中央动脉的作用。已知该血管有丰富的交感神经支配（德拉兰德、弗鲁因和沃特森，1967年），并且还有一个额外的优势，即可以通过手术去除其神经支配。因此，就有可能检测乙基肾上腺素对正常动脉和去神经动脉的影响，并定量该药物在其血管收缩作用中依赖交感神经的程度。