Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Banjara Hills, Hyderabad, Telangana; Department of Retina and Uveitis, GMR Varalakshmi Campus, L V Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India.
Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Banjara Hills, Hyderabad, Telangana, India.
Indian J Ophthalmol. 2020 Jan;68(1):118-122. doi: 10.4103/ijo.IJO_528_19.
The aim of this study is to report the prevalence, clinical and swept-source optical coherence tomography (SS-OCT) characteristics of pachydrusen in eyes with central serous chorioretinopathy (CSCR) and their fellow eyes.
A total of 264 eyes of 132 patients with a diagnosis of CSCR (acute/persistent/recurrent/chronic/inactive) in atleast one eye, were analyzed in this retrospective, cross-sectional study. SS-OCT parameters including choroidal thickness (CT), large choroidal vessel layer thickness (LCVT) at fovea and the site of pachydrusen were recorded. Paired t test and analysis of variance (ANOVA) was used to compare CT in eyes with CSCR (subfoveal and site of pachydrusen) and multiple groups respectively.
The mean age of the study patients was 42.9 ± 9.5 years with 119 males (90.15%). Bilateral CSCR was present in 31 patients. Nine eyes (chronic, 4; persistent, 2; and inactive/resolved CSCR, 3) showed presence of pachydrusen with an overall prevalence of 6.82% (9 eyes of 9 patients out of 132 patients). There was no significant difference of subfoveal CT (SFCT) in eyes with CSCR (422.4 ± 107.8 μ) vs fellow eyes (407.0 ± 96.5 μ) and eyes with CSCR associated with pachydrusen (413.7 ± 101.5 μ) vs fellow eyes of CSCR eyes with pachydrusen (431.6 ± 188.8 μ) (P = 0.71). LCVT as a percentage of CT was higher at the site of pachydrusen compared to SFCT (69.8% vs. 50.8%).
CSCR can be associated with pachydrusen with a lower prevalence rate than previously reported. Whether the thickened large choroidal vessels at site of pachydrusen play any role in formation in pachydrusen needs further evaluation.
本研究旨在报告伴有中心性浆液性脉络膜视网膜病变（CSCR）的眼和对侧眼的大泡性脉络膜病变（pachydrusen）的患病率、临床和扫频源光学相干断层扫描（SS-OCT）特征。
本回顾性、横断面研究共分析了 132 例患者的 264 只眼，这些患者的至少一只眼被诊断为 CSCR（急性/持续性/复发性/慢性/非活动）。记录 SS-OCT 参数，包括脉络膜厚度（CT）、黄斑区大脉络膜血管层厚度（LCVT）和大泡性脉络膜病变部位。采用配对 t 检验和方差分析（ANOVA）分别比较 CSCR 眼（黄斑下和大泡性脉络膜病变部位）和多组之间的 CT。
研究患者的平均年龄为 42.9 ± 9.5 岁，男性 119 例（90.15%）。31 例患者为双眼 CSCR。9 只眼（慢性 4 只；持续性 2 只；非活动/消退 CSCR 3 只）存在大泡性脉络膜病变，总患病率为 6.82%（9 只眼/9 例患者/132 例患者）。CSCR 眼的黄斑下 CT（SFCT）（422.4 ± 107.8 μ）与对侧眼（407.0 ± 96.5 μ）和 CSCR 伴大泡性脉络膜病变眼的对侧眼（413.7 ± 101.5 μ）之间无显著差异（P = 0.71）。大泡性脉络膜病变部位的 LCVT 占 CT 的百分比高于 SFCT（69.8% vs. 50.8%）。
CSCR 可伴有大泡性脉络膜病变，其患病率低于既往报道。大泡性脉络膜病变部位增厚的大脉络膜血管是否在大泡性脉络膜病变的形成中起作用需要进一步评估。
