Department of Ophthalmology, Korea University College of Medicine, Seoul 02841, Korea.
Department of Ophthalmology, Ajou University School of Medicine, Suwon 16499, Korea.
Int J Mol Sci. 2022 Jul 28;23(15):8353. doi: 10.3390/ijms23158353.
We investigated the relationship between pachydrusen and choroidal thickness and age in eyes with polypoidal choroidal vasculopathy (PCV) and fellow eyes, compared to eyes with central serous chorioretinopathy (CSC). This retrospective study included 89 eyes with PCV and 146 eyes with CSC. The number, location, and shape of the pachydrusen and their association with choroidal thickness and age were analyzed. PCV eyes showed pachydrusen more frequently than eyes with CSC (52% vs. 20%, p < 0.001). Large solitary type and clustered type were more frequent in PCV eyes compared to CSC eyes (p = 0.003 and p = 0.001, respectively). Subfoveal choroidal thickness was associated with pachydrusen in eyes with PCV (odds ratio [OR] 1.006, 95% confidence interval [CI] 1.001−1.011, p = 0.027), while age was associated with pachydrusen in CSC eyes (OR 1.137, 95% CI, 1.073−1.205; p < 0.001). Pachydrusen were localized directly over the pachyvessel on optical coherence tomographic findings in approximately two thirds of PCV eyes and fellow eyes (62% and 67%, respectively). Risk factors for pachydrusen differ according to diseases. The presence of pachydrusen was associated with choroidal thickness in PCV, while the association with age was more prominent in CSC.
我们研究了多灶性脉络膜血管病（PCV）眼和对侧眼与中心性浆液性脉络膜视网膜病变（CSC）眼之间厚脉络膜与年龄的关系。这项回顾性研究包括 89 只 PCV 眼和 146 只 CSC 眼。分析了多灶性脉络膜血管病眼的多灶性脉络膜血管病的数量、位置和形状及其与脉络膜厚度和年龄的关系。PCV 眼比 CSC 眼更频繁地出现多灶性脉络膜血管病（52%比 20%，p<0.001）。与 CSC 眼相比，PCV 眼更常见大型孤立型和聚集型多灶性脉络膜血管病（p=0.003 和 p=0.001）。PCV 眼的脉络膜下厚度与多灶性脉络膜血管病有关（优势比[OR]1.006，95%置信区间[CI]1.001−1.011，p=0.027），而年龄与 CSC 眼的多灶性脉络膜血管病有关（OR 1.137，95%CI，1.073−1.205；p<0.001）。在大约三分之二的 PCV 眼和对侧眼的光学相干断层扫描结果中，多灶性脉络膜血管病直接位于厚脉络膜血管上（分别为 62%和 67%）。多灶性脉络膜血管病的危险因素因疾病而异。PCV 中多灶性脉络膜血管病与脉络膜厚度有关，而 CSC 中与年龄的关系更为明显。
