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巴西一家三级医院重症监护病房患者分离的鲍曼不动杆菌碳青霉烯酶和氨基糖苷修饰酶研究。

Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil.

机构信息

Instituto Adolfo Lutz, Centro de Laboratório Regional de São José do Rio Preto, São José do Rio Preto, SP, Brasil.

Faculdade de Medicina de São José do Rio Preto, Centro de Investigação de Microrganismos, São José do Rio Preto, SP, Brasil.

出版信息

Rev Soc Bras Med Trop. 2019 Dec 20;53:e20190044. doi: 10.1590/0037-8682-0094-2019. eCollection 2019.

DOI:10.1590/0037-8682-0094-2019
PMID:31859941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7083385/
Abstract

INTRODUCTION

Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs).

METHODS

Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital.

RESULTS

The key genes found were bla OXA-51-like, the association ISAba1- bla OXA-23-like, and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards.

CONCLUSIONS

The dissemination of bla OXA-23-like and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.

摘要

简介

鲍曼不动杆菌是一种机会性细菌，通过产生碳青霉烯酶和氨基糖苷修饰酶（AMEs），能够高度获得抗微生物药物的耐药性。

方法

研究了从巴西一家医院住院患者中分离出的鲍曼不动杆菌中的碳青霉烯酶和 AME 基因。

结果

发现的关键基因是 bla OXA-51-like，ISAba1- bla OXA-23-like 的关联，以及 AME 基因 aph(3´)-VI、aac(6´)-Ib、aac(3)-Ia 和 aph(3´)-Ia。不同的簇在医院病房中传播。

结论

bla OXA-23-like 和携带 AME 的鲍曼不动杆菌在医院的传播突出表明需要改进预防措施以减少感染的传播。

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