伴有1型浦肯野细胞抗体的副肿瘤性运动神经元病

Paraneoplastic motor neuron disease with type 1 Purkinje cell antibodies.

作者信息

Khwaja S, Sripathi N, Ahmad B K, Lennon V A

机构信息

Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA.

出版信息

Muscle Nerve. 1998 Jul;21(7):943-5. doi: 10.1002/(sici)1097-4598(199807)21:7<943::aid-mus14>3.0.co;2-r.

DOI:10.1002/(sici)1097-4598(199807)21:7<943::aid-mus14>3.0.co;2-r

PMID:9626256

Abstract

Autoimmune serological testing is a useful aid for identifying a paraneoplastic basis for sporadic motor neuron disease. A 67-year-old woman with ovarian carcinoma presented with progressive weakness. Neurological examination was suggestive of motor neuron disease with signs of upper motor neuron disorder. Electromyography revealed severe motor neuronopathy of the upper extremities. Characteristic type 1 Purkinje cell antibodies (anti-Yo antibody) was detected in the serum diluted at 1:61,400.

摘要

自身免疫血清学检测有助于识别散发性运动神经元病的副肿瘤性病因。一名67岁的卵巢癌女性出现进行性肌无力。神经系统检查提示为运动神经元病伴上运动神经元障碍体征。肌电图显示上肢严重运动神经元病。在稀释至1:61,400的血清中检测到特征性的1型浦肯野细胞抗体（抗Yo抗体）。