Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 020956 Bucharest, Romania.
Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 010221 Bucharest, Romania.
Biomolecules. 2019 Dec 17;9(12):884. doi: 10.3390/biom9120884.
It is currently recognized that an injudicious strategy about caries in the last decades has been not only focusing of research mostly in children, but also the narrow focusing on fluoride, because despite sufficient availability of fluoride in water and oral healthcare products, caries levels escalate steadily as people get older and caries remain a main public health issue to be settled. In the last two decades the scientific community intensified efforts of exploring other products for caries prevention, herbal products being one of these approaches. Preliminary evidence indicated that clinical trials for caries prevention with herbal products are heterogeneous in design, quality and products evaluated, we therefore performed a scoping review intended to explore the main characteristics of such clinical trials. From an initial collection of 1986 unique papers from different literature databases, 56 articles satisfied the inclusion and exclusion criteria. The species investigated, dosage forms, study designs, duration of intervention, controls, endpoints, quality of reporting, and risk of bias are discussed. Of the trials reviewed here, 85.71% reported positive results but given the methodological flaws and biases affecting them, it is difficult to conclude on the efficacy of those products based on the studies published thus far.
目前人们认识到，过去几十年中在龋齿防治方面的策略并不明智，不仅研究重点主要集中在儿童身上，而且还局限于氟化物，因为尽管饮用水和口腔保健产品中有足够的氟化物供应，但随着人们年龄的增长，龋齿的发病率仍在稳步上升，龋齿仍然是一个亟待解决的主要公共卫生问题。在过去的二十年中，科学界加大了力度探索其他用于龋齿预防的产品，草药产品就是其中一种方法。初步证据表明，用于龋齿预防的草药产品临床试验在设计、质量和评估产品方面存在差异，因此我们进行了范围综述，旨在探索此类临床试验的主要特征。从不同文献数据库中最初收集的 1986 篇独特论文中，有 56 篇文章符合纳入和排除标准。讨论了所研究的物种、剂型、研究设计、干预持续时间、对照组、终点、报告质量和偏倚风险。在审查的试验中，85.71%报告了阳性结果，但鉴于影响这些结果的方法学缺陷和偏差，很难根据迄今为止发表的研究来得出这些产品的疗效结论。
