Michalek-Zrabkowska Monika, Martynowicz Helena, Wieckiewicz Mieszko, Smardz Joanna, Poreba Rafal, Mazur Grzegorz
Department of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 213 Borowska St., 50-556 Wroclaw, Poland.
Department of Experimental Dentistry, Wroclaw Medical University, 26 Krakowska St., 50-425 Wroclaw, Poland.
J Clin Med. 2021 May 21;10(11):2245. doi: 10.3390/jcm10112245.
Sleep bruxism is a common sleep-related behavior characterized as repetitive masticatory muscle activity. Genetic vulnerability to stress and anxiety is considered a basal component in the pathogenesis of bruxism events. Dysfunction of the autonomic nervous system related with an arousal during sleep is considered an underlying cause of the cardiovascular implications of sleep bruxism. Increased cardiovascular risk was previously linked with sleep conditions: for example, obstructive sleep apnea and insomnia, and sleep bruxism. The aim of present systematic review was to evaluate the current arguments on the relationship between sleep bruxism and cardiovascular diseases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We have reviewed the Embase, PubMed (Medline) and Scopus databases to identify applicable articles (1994-2021). A total of 127 records in English language were identified, then after screening and exclusion of nonrelevant records, 19 full-text articles were evaluated. Finally, we included 12 studies for synthesis. Due to the heterogeneity of the compared studies, only a qualitative comparison and narrative summary were performed. In the majority of studies, increased sympathetic activity was successfully established to escalate heart rate variability, the inflammatory process, oxidative stress, endothelial remodeling and hormonal disturbances, leading to hypertension and other cardiovascular complications.
睡眠磨牙症是一种常见的与睡眠相关的行为，其特征为重复性咀嚼肌活动。对应激和焦虑的遗传易感性被认为是磨牙症发病机制的一个基本组成部分。与睡眠中觉醒相关的自主神经系统功能障碍被认为是睡眠磨牙症心血管影响的潜在原因。心血管风险增加以前与睡眠状况有关，例如阻塞性睡眠呼吸暂停、失眠和睡眠磨牙症。本系统评价的目的是根据系统评价和Meta分析的首选报告项目（PRISMA）评估目前关于睡眠磨牙症与心血管疾病之间关系的观点。我们检索了Embase、PubMed（Medline）和Scopus数据库以识别适用的文章（1994 - 2021年）。共识别出127篇英文记录，在筛选和排除不相关记录后，对19篇全文文章进行了评估。最后，我们纳入了12项研究进行综合分析。由于所比较研究的异质性，仅进行了定性比较和叙述性总结。在大多数研究中，已成功证实交感神经活动增加会加剧心率变异性、炎症过程、氧化应激、内皮重塑和激素紊乱，从而导致高血压和其他心血管并发症。
