Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
Sci Rep. 2019 Dec 20;9(1):19564. doi: 10.1038/s41598-019-55926-w.
We examined the association between Bruch's membrane opening (BMO) area and various ocular parameters and investigated the implication of BMO enlargement on the myopic optic nerve head. One hundred eighty-five myopic eyes were included in this cross-sectional study. Among the included eyes, 53 having axial lengths between 26 and 27 mm were further analyzed to investigate the association between BMO area and various ocular parameters. BMO area, BMO-minimum rim width (BMO-MRW), peripapillary choroidal thickness (pCT), width of β-parapapillary atrophy with and without Bruch's membrane (PPA and PPA), and presence of lamina cribrosa (LC) defect were evaluated. We found that BMO area tended to increase with increasing axial length, but varied among the highly myopic eyes even though they had similar degrees of myopia. In the subgroup analysis of eyes with axial lengths between 26 and 27 mm, BMO area was highly variable and it significantly correlated with PPA width and temporal-inferior, nasal-inferior, and nasal BMO-MRW and pCT. LC defects were more common in myopic eyes with enlarged BMO. A multivariate regression model revealed that higher intraocular pressure, enlarged BMO, and thinner BMO-MRW were associated with LC defects in highly myopic eyes. These findings should be considered when evaluating myopic eyes.
我们研究了脉络膜上腔开口（BMO）面积与各种眼部参数之间的关系，并探讨了 BMO 扩大对近视性视神经头的影响。本横断面研究纳入了 185 只近视眼。在纳入的眼中，进一步分析了 53 只眼轴长度在 26 至 27mm 之间的眼，以研究 BMO 面积与各种眼部参数之间的关系。评估了 BMO 面积、BMO 最小边缘宽度（BMO-MRW）、脉络膜旁厚度（pCT）、有和无脉络膜（PPA 和 PPA）的β-旁视盘萎缩的宽度以及筛板（LC）缺陷。我们发现 BMO 面积随眼轴长度的增加而增加，但在高度近视眼中变化较大，尽管它们的近视程度相似。在眼轴长度为 26 至 27mm 的亚组分析中，BMO 面积的变化很大，与 PPA 宽度以及颞下、鼻下和鼻侧 BMO-MRW 和 pCT 显著相关。LC 缺陷在 BMO 增大的近视眼中更为常见。多元回归模型显示，高眼压、BMO 增大和 BMO-MRW 变薄与高度近视眼中的 LC 缺陷有关。在评估近视眼时应考虑这些发现。
