Research Department of Pathology, Cancer Institute, University College London, London, WC1E 6BT, UK.
Research Department of Pathology, Cancer Institute, University College London, London, WC1E 6BT, UK; Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK.
Semin Cancer Biol. 2020 Apr;61:42-55. doi: 10.1016/j.semcancer.2019.11.009. Epub 2019 Dec 19.
Undifferentiated sarcoma of soft tissue (USTS) are aggressive sarcomas that remain a diagnosis of exclusion and show extreme genomic complexity. Many advances in diagnostic criteria have resulted in several revisions in the definition of this rare cancer type. Recent sequencing efforts have illuminated the nature of the genome complexity and have revealed extensive copy number heterogeneity and multiple evolutionary patterns of development. This review places these recent advances into their historical and translational context and covers the changes in nomenclature, molecular classification, and the promise of personalised medicine.
未分化软组织肉瘤（USTS）是一种侵袭性肉瘤，其始终是一种排他性诊断，表现出极端的基因组复杂性。在诊断标准方面的许多进展导致了对这种罕见癌症类型定义的几次修订。最近的测序工作阐明了基因组复杂性的本质，并揭示了广泛的拷贝数异质性和多种发育进化模式。本综述将这些最新进展置于其历史和转化背景下，并涵盖了命名法、分子分类的变化以及个性化医疗的前景。
