Shait Mohammed Mohammed Razeeth, Ahmad Varish, Ahmad Abrar, Tabrez Shams, Choudhry Hani, Zamzami Mazin A, Bakhrebah Muhammed A, Ahmad Aftab, Wasi Samina, Mukhtar Hasan, Khan Mohammad Imran
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Health Information Technology Department,Faculty of Applied Studies, King Abdulaziz University, Jeddah, Saudi Arabia.
Semin Cancer Biol. 2021 Feb;69:129-139. doi: 10.1016/j.semcancer.2019.12.015. Epub 2019 Dec 19.
Nano metal organic frameworks (NMOFs) belong to the group of nanoporous materials. Over the decades, the conducted researches explored the area for the potential applications of NMOFs in areas like biomedical, chemical engineering and materials science. Recently, NMOFs have been explored for their potential use in cancer diagnosis and therapeutics. The excellent physico-chemical features of NMOFs also make them a potential candiadate to facilitate drug design, delivery and storage against cancer cells. In this review, we have explored the characterstic features, synthesis methods, NMOFs based drug delivery, diagnosis and imaging in various cancer types. In addition to this, we have also pondered on the stability and toxicological concerns of NMOFs. Despite, a significant research has been done for the potential use of NMOFs in cancer diagonostic and therapeutics, more information regarding the stability, in-vivo clearance, toxicology, and pharmacokinetics is still needed to ehnace the use of NMOFs in cancer diagonostic and therapeutics.
纳米金属有机框架(NMOFs)属于纳米多孔材料类别。几十年来,开展的研究探索了NMOFs在生物医学、化学工程和材料科学等领域的潜在应用领域。最近,人们对NMOFs在癌症诊断和治疗中的潜在用途进行了探索。NMOFs优异的物理化学特性也使其成为促进抗癌药物设计、递送和储存的潜在候选物。在本综述中,我们探讨了NMOFs的特征、合成方法、基于NMOFs的药物递送、在各种癌症类型中的诊断和成像。除此之外,我们还思考了NMOFs的稳定性和毒理学问题。尽管已经对NMOFs在癌症诊断和治疗中的潜在用途进行了大量研究,但仍需要更多关于稳定性、体内清除率、毒理学和药代动力学的信息,以加强NMOFs在癌症诊断和治疗中的应用。