Department of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Institute of Brain Functional Imaging, Nanjing Medical University, Nanjing, Jiangsu, China.
Hum Brain Mapp. 2020 May;41(7):1786-1796. doi: 10.1002/hbm.24911. Epub 2019 Dec 28.
Glioma can cause variable alterations to the structure and function of the brain. However, there is a paucity of studies on the gray matter (GM) volume alterations in the brain region opposite the temporal glioma before and after surgery. Therefore, the present study was initiated to investigate the alternation in contralateral homotopic GM volume in patients with unilateral temporal lobe glioma and further, assess the relationship between GM volume alternations with cognition. Eight left temporal lobe glioma patients (LTPs), nine right temporal lobe glioma patients (RTPs), and 28 demographically matched healthy controls (HCs) were included. Using voxel-based morphometry method, alternations in the contralateral homotopic GM volume in patients with unilateral temporal lobe glioma was determined. Furthermore, the correlation analysis was performed to explore the relationship between cognitive function and altered GM volume. In the preoperative analysis, compared to HCs, LTPs exhibited increased GM volume in right inferior temporal gyrus and right temporal pole (superior temporal gyrus), and, RTPs presented increased GM volume in left inferior temporal gyrus. In the postoperative analysis, compared to HCs, RTPs presented increased GM volume in left middle temporal gyrus. Furthermore, the increased GM volume was significantly positively correlated with the memory test but negatively correlated with the visuospatial test. This study preliminarily confirmed that there were compensatory changes in the GM volume in the contralateral temporal lobe in unilateral temporal lobe glioma patients. Furthermore, alterations of GM volume may be a mechanism for cognitive function compensation.
脑胶质瘤可导致大脑结构和功能的多种改变。然而，目前关于手术前后肿瘤对侧颞叶脑区灰质（GM）体积改变的研究较少。因此，本研究旨在探讨单侧颞叶胶质瘤患者对侧同源 GM 体积的改变，并进一步评估 GM 体积改变与认知功能的关系。纳入 8 例左侧颞叶胶质瘤患者（LTP）、9 例右侧颞叶胶质瘤患者（RTP）和 28 例年龄匹配的健康对照者（HCs）。采用基于体素的形态学方法，确定单侧颞叶胶质瘤患者对侧同源 GM 体积的改变。此外，进行相关性分析，以探讨认知功能与 GM 体积改变的关系。在术前分析中，与 HCs 相比，LTP 患者右侧颞下回和右侧颞极（颞上回）GM 体积增加，RTP 患者左侧颞下回 GM 体积增加。在术后分析中，与 HCs 相比，RTP 患者左侧颞中回 GM 体积增加。此外，GM 体积的增加与记忆测试呈显著正相关，与视空间测试呈显著负相关。本研究初步证实，单侧颞叶胶质瘤患者对侧颞叶 GM 体积存在代偿性改变。此外，GM 体积的改变可能是认知功能代偿的一种机制。
