Manso-Ortega Lucía, De Frutos-Sagastuy Laura, Gisbert-Muñoz Sandra, Salamon Noriko, Qiao Joe, Walshaw Patricia, Quiñones Ileana, Połczyńska Monika M
Neurobiology of Language Group, Basque Center on Cognition, Brain and Language (BCBL), 20009 Donostia-San Sebastián, Spain.
Department of Basque Language and Communication, University of the Basque Country, UPV/EHU, 48940 Bilbao, Spain.
Cancers (Basel). 2023 Jul 28;15(15):3852. doi: 10.3390/cancers15153852.
A brain tumor in the left hemisphere can decrease language laterality as assessed through fMRI. However, it remains unclear whether or not this decreased language laterality is associated with a structural reshaping of the grey matter, particularly within the language network. Here, we examine if the disruption of the language hubs exclusively affects the macrostructural properties of the contralateral homologues or whether it affects both hemispheres. This study uses voxel-based morphometry applied to high-resolution MR T1-weighted MPRAGE images from 31 adult patients' left hemisphere, which is dominant for language. Eighteen patients had brain tumors in the left hemisphere, and thirteen had tumors in the right hemisphere. A cohort of 71 healthy individuals matched with respect to age and sex was used as a baseline. We defined 10 ROIs per hemisphere involved in language function. Two separate repeated-measure ANOVAs were conducted with the volume per region as the dependent variable. For the patients, tumor lateralization (right versus left) served as a between-subject factor. The current study demonstrated that the presence of a brain tumor generates global volumetric changes affecting the left language regions and their contralateral homologues. These changes are mediated by the lateralization of the lesion. Our findings suggest that functional mechanisms are supported by the rearrangement of the grey matter.
通过功能磁共振成像（fMRI）评估，左半球的脑肿瘤会降低语言偏侧化。然而，目前尚不清楚这种降低的语言偏侧化是否与灰质的结构重塑有关，特别是在语言网络内。在这里，我们研究语言中枢的破坏是否仅影响对侧同源物的宏观结构特性，或者是否影响两个半球。本研究使用基于体素的形态测量法，应用于31名成年患者左半球的高分辨率MR T1加权MPRAGE图像，该半球以语言功能为主。18名患者左半球有脑肿瘤，13名患者右半球有肿瘤。以71名年龄和性别匹配的健康个体作为基线。我们在每个半球定义了10个参与语言功能的感兴趣区域（ROI）。以每个区域的体积作为因变量进行了两次独立的重复测量方差分析。对于患者，肿瘤的侧别（右侧与左侧）作为受试者间因素。当前研究表明，脑肿瘤的存在会产生影响左侧语言区域及其对侧同源物的整体体积变化。这些变化由病变的侧别介导。我们的研究结果表明，功能机制由灰质的重新排列支持。
