[急性敌百虫中毒时神经肌肉装置的临床形态学和组织化学变化]

[Clinico-morphologic and histochemical changes in the neuromuscular apparatus in acute carbophos poisoning].

作者信息

Kolesnichenko I P, Buchko V M, Vladeeva N V

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(7):76-80.

Abstract

Clinical analysis of 378 acute cases of Malathion insecticide intoxication and pathological and histochemical investigation of skeletal muscles in 7 autopsied victims of acute poisoning have revealed the pronounced neuromuscular disorders. Generalized paresis and paralysis of muscles were observed in trunk and limbs. Muscular fasciculation, hypotonia and hyporeflexia were also generalized. Multiple foci of muscular fibers necrosis and necrobiosis were found with intermuscular nerves and motor endings degenerated, neuromuscular junctions cholinesterase sharply inactivated.

摘要

对378例急性马拉硫磷杀虫剂中毒病例的临床分析以及对7例急性中毒尸检受害者骨骼肌的病理和组织化学研究显示出明显的神经肌肉紊乱。在躯干和四肢观察到全身性肌无力和肌肉麻痹。肌肉束颤、肌张力减退和反射减弱也普遍存在。发现多处肌纤维坏死和渐进性坏死灶，肌间神经和运动终板退化，神经肌肉接头处胆碱酯酶急剧失活。