Marin-Barrera Lucia, Muñoz-Martin Andres J, Rios-Herranz Eduardo, Garcia-Escobar Ignacio, Beato Carmen, Font Carme, Oncala-Sibajas Estefania, Revuelta-Rodriguez Alfonso, Areses Maria Carmen, Rivas-Jimenez Victor, Moreno-Santos Maria Angeles, Ballaz-Quincoces Aitor, Lopez-Saez Juan-Bosco, Gallego Iria, Elias-Hernandez Teresa, Asensio-Cruz Maria Isabel, Chasco-Eguilaz Leyre, Garcia-Gonzalez Gonzalo, Estevez-Garcia Purificacion, Otero Remedios, Lima-Alvarez Jorge, Jara-Palomares Luis
Respiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, CIBERES, 41013 Sevilla, Spain.
Medical Oncology Department, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain.
Cancers (Basel). 2019 Dec 26;12(1):75. doi: 10.3390/cancers12010075.
Although there is published research on the impact of venous thromboembolism (VTE) on quality of life (QoL), this issue has not been thoroughly investigated in patients with cancer-particularly using specific questionnaires. We aimed to examine the impact of acute symptomatic VTE on QoL of patients with malignancies. This was a multicenter, prospective, case-control study conducted in patients with cancer either with (cases) or without (controls) acute symptomatic VTE. Participants completed the EORTC QLQ-C30, EQ-5D-3L, PEmb-QoL, and VEINES-QOL/Sym questionnaires. Statistically significant and clinically relevant differences in terms of global health status were examined. Between 2015 and 2018, we enrolled 425 patients (128 cases and 297 controls; mean age: 60.2 ± 18.4 years). The most common malignancies were gastrointestinal (23.5%) and lung (19.8%) tumors. We found minimally important differences in global health status on the EQ-5D-3L (cases versus controls: 0.55 versus 0.77; mean difference: -0.22) and EORTC QLQ-C30 (47.7 versus 58.4; mean difference: -10.3) questionnaires. There were minimally important differences on the PEmb-QoL questionnaire (44.4 versus 23; mean difference: -21.4) and a significantly worse QoL on the VEINES-QOL/Sym questionnaire (42.7 versus 51.7; mean difference: -9). In conclusion, we showed that acute symptomatic VTE adversely affects the QoL of patients with malignancies.
尽管已有关于静脉血栓栓塞症（VTE）对生活质量（QoL）影响的研究发表，但在癌症患者中，这一问题尚未得到充分研究，尤其是未使用特定问卷进行研究。我们旨在研究急性症状性VTE对恶性肿瘤患者生活质量的影响。这是一项多中心、前瞻性、病例对照研究，研究对象为患有（病例组）或未患有（对照组）急性症状性VTE的癌症患者。参与者完成了欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30）、欧洲五维度健康量表（EQ-5D-3L）、PEmb-QoL问卷和静脉血栓栓塞症生活质量/症状问卷（VEINES-QOL/Sym）。研究人员对全球健康状况方面具有统计学意义和临床相关性的差异进行了检验。在2015年至2018年期间，我们招募了425名患者（128例病例和297例对照；平均年龄：60.2±18.4岁）。最常见的恶性肿瘤是胃肠道肿瘤（23.5%）和肺癌（19.8%）。我们发现，在EQ-5D-3L问卷（病例组与对照组：0.55对0.77；平均差异：-0.22）和EORTC QLQ-C30问卷（47.7对58.4；平均差异：-10.3）上，全球健康状况存在最小重要差异。在PEmb-QoL问卷上存在最小重要差异（44.4对23；平均差异：-21.4），在VEINES-QOL/Sym问卷上生活质量显著更差（42.7对51.7；平均差异：-9）。总之，我们表明急性症状性VTE对恶性肿瘤患者的生活质量有不利影响。
