Davis Danielle R, Miller Mollie E, Streck Joanna M, Bergeria Cecilia L, Sigmon Stacey C, Tidey Jennifer W, Heil Sarah H, Gaalema Diann E, Villanti Andrea C, Stitzer Maxine L, Priest Jeff S, Bunn Janice Y, Skelly Joan M, Diaz Valeria, Arger Christopher A, Higgins Stephen T
UVM Tobacco Center on Regulatory Science, Departments of Psychiatry and Psychological Science, University of Vermont, Burlington, VT.
Center for Alcohol and Addiction Studies, Brown University, Providence, RI.
Tob Regul Sci. 2019 Mar;5(2):135-142. doi: 10.18001/TRS.5.2.5.
In this study, we investigated potential effects of being a menthol smoker on response to reduced nicotine content (RNC) cigarettes in smokers especially vulnerable to smoking.
Participants were 169 smokers (61 menthol and 108 non-menthol smokers) with comorbid mental illness, substance use disorder, or socioeconomic disadvantage. Participants completed a double-blind study assessing addiction potential, withdrawal/craving, and compensatory smoking across 4 research cigarettes varying in nicotine content from very low levels to commercial levels (0.4, 2.4, 5.2, 15.8mg/g of tobacco). Repeated measures analysis of variance was used to examine potential moderating effects of menthol status.
Statistically significant effects of nicotine dose were noted across measures, with higher doses producing greater economic demand and relief from withdrawal/craving. The relationships between nicotine dose and response to RNC cigarettes do not differ by menthol status.
Results of this study suggest menthol does not have a differential impact on response to RNC cigarettes across measures of economic demand, withdrawal/craving, or smoking topography. These results suggest that any potential beneficial effects of RNC cigarettes should extend to menthol smokers including those especially vulnerable to smoking.
在本研究中，我们调查了吸薄荷醇香烟对吸烟易感性较高的吸烟者对尼古丁含量降低（RNC）香烟反应的潜在影响。
参与者为169名患有共病精神疾病、物质使用障碍或社会经济劣势的吸烟者（61名吸薄荷醇香烟者和108名不吸薄荷醇香烟者）。参与者完成了一项双盲研究，评估了4种尼古丁含量从极低水平到商业水平（0.4、2.4、5.2、15.8mg/g烟草）的研究用香烟的成瘾潜力、戒断/渴望和代偿性吸烟情况。采用重复测量方差分析来检验薄荷醇状态的潜在调节作用。
在各项测量中均观察到尼古丁剂量具有统计学显著效应，较高剂量产生更大的经济需求并缓解戒断/渴望。尼古丁剂量与对RNC香烟反应之间的关系不因薄荷醇状态而异。
本研究结果表明，在经济需求、戒断/渴望或吸烟行为特征等测量方面，薄荷醇对RNC香烟反应没有差异影响。这些结果表明，RNC香烟的任何潜在有益效果都应适用于吸薄荷醇香烟者，包括那些吸烟易感性较高的人群。
