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美国痴呆症误诊风险中的种族差异与时间趋势

Racial disparities and temporal trends in dementia misdiagnosis risk in the United States.

作者信息

Gianattasio Kan Z, Prather Christina, Glymour M Maria, Ciarleglio Adam, Power Melinda C

机构信息

Department of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.

Department of Medicine, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.

出版信息

Alzheimers Dement (N Y). 2019 Dec 9;5:891-898. doi: 10.1016/j.trci.2019.11.008. eCollection 2019.

Abstract

INTRODUCTION

Systematic disparities in misdiagnosis of dementia across racial/ethnic groups have implications for health disparities. We compared the risk of dementia under- and overdiagnosis in clinical settings across racial/ethnic groups from 2000 to 2010.

METHODS

We linked fee-for-service Medicare claims to participants aged ≥70 from the nationally representative Health and Retirement Study. We classified dementia status using an algorithm with similar sensitivity and specificity across racial/ethnic groups and assigned clinical dementia diagnosis status using ICD-9-CM codes from Medicare claims. Multinomial logit models were used to estimate relative risks of clinical under- and overdiagnosis between groups and over time.

RESULTS

Non-Hispanic blacks had roughly double the risk of underdiagnosis as non-Hispanic whites. While primary analyses suggested a shrinking disparity over time, this was not robust to sensitivity analyses or adjustment for covariates. Risk of overdiagnosis increased over time in both groups.

DISCUSSION

Our results suggest that efforts to reduce racial disparities in underdiagnosis are warranted.

摘要

引言

不同种族/族裔群体在痴呆症误诊方面存在系统性差异,这对健康差异有影响。我们比较了2000年至2010年不同种族/族裔群体在临床环境中痴呆症诊断不足和诊断过度的风险。

方法

我们将按服务收费的医疗保险索赔与具有全国代表性的健康与退休研究中年龄≥70岁的参与者相联系。我们使用一种在不同种族/族裔群体中具有相似敏感性和特异性的算法对痴呆症状态进行分类,并使用医疗保险索赔中的ICD-9-CM编码确定临床痴呆症诊断状态。多项logit模型用于估计不同群体之间以及随时间推移临床诊断不足和诊断过度的相对风险。

结果

非西班牙裔黑人诊断不足的风险大约是非西班牙裔白人的两倍。虽然初步分析表明随着时间的推移差距在缩小,但在敏感性分析或对协变量进行调整时,这并不稳健。两组的诊断过度风险都随时间增加。

讨论

我们的结果表明,有必要努力减少诊断不足方面的种族差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f72/6926355/3dae516cec2e/gr1.jpg

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