Ishak K G, Willis G W, Cummins S D, Bullock A A
Cancer. 1977 Jan;39(1):322-38. doi: 10.1002/1097-0142(197701)39:1<322::aid-cncr2820390149>3.0.co;2-p.
The clinical and pathologic features and long-term follow-up of eight patients with biliary cystadenoma and six patients with biliary cystadenocarcinoma are reported and the previous literature is reviewed. All the cystadenomas were in middle-aged women, but the six cystadenocarcinomas occurred in both male (4) and female (2) patients. The majority of the patients with cystadenoma and half of those with cystadenocarcinoma presented with an abdominal mass. Four of the patients whose cystadenoma was excised are alive and well for periods of time ranging from 2 1/2 to 13 years. Two of the patients with cystadenocarcinoma have survived for three years and for three years and eight months, respectively, after subtotal hepatic lobectomy. Morphologically the cystadenocarcinomas differ from the cystadenomas in that the former have cellular pleomorphism and anaplasia and infiltration of the underlying fribrous stroma; they can invade adjacent viscera and may occasionally metastasize to distant sites. The presence of benign epithelium in most cystadenocarcinomas supports their origin from cystadenoma.
报告了8例胆管囊腺瘤患者和6例胆管囊腺癌患者的临床及病理特征，并对既往文献进行了回顾。所有囊腺瘤患者均为中年女性，但6例囊腺癌患者中男性4例，女性2例。大多数囊腺瘤患者和一半的囊腺癌患者表现为腹部肿块。4例行囊腺瘤切除术的患者存活良好，时间为2年半至13年不等。2例囊腺癌患者在肝叶次全切除术后分别存活了3年和3年8个月。形态学上，囊腺癌与囊腺瘤不同，前者具有细胞多形性、间变及对下方纤维基质的浸润；它们可侵犯邻近脏器，偶尔可转移至远处部位。大多数囊腺癌中存在良性上皮，这支持了它们起源于囊腺瘤的观点。
