血小板衍生的微小RNA作为氯吡格雷治疗的急性冠状动脉综合征患者抗血小板反应的决定因素。 - Suppr

Platelet-derived miRNAs as determinants of the antiplatelet response in clopidogrel-treated patients with ACS.

作者信息

Liu Jun, Qin Liuan, Wang Ziqian, Peng Li, Liu Jia, Wang Xuyun, Du Rina, Zou Yuting, Wu Yangxun, Yin Tong

机构信息

Department of Cardiology, First Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.

出版信息

Thromb Res. 2020 Feb;186:71-74. doi: 10.1016/j.thromres.2019.12.016. Epub 2019 Dec 24.

DOI:10.1016/j.thromres.2019.12.016

PMID:31891827

Abstract

摘要

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Platelet-derived miRNAs as determinants of the antiplatelet response in clopidogrel-treated patients with ACS.血小板衍生的微小RNA作为氯吡格雷治疗的急性冠状动脉综合征患者抗血小板反应的决定因素。

Thromb Res. 2020 Feb;186:71-74. doi: 10.1016/j.thromres.2019.12.016. Epub 2019 Dec 24.

Diurnal Variability of On-Treatment Platelet Reactivity in Clopidogrel versus Prasugrel Treated Acute Coronary Syndrome Patients: A Pre-Specified TROPICAL-ACS Sub-Study.氯吡格雷与普拉格雷治疗急性冠状动脉综合征患者治疗中的血小板反应性的日间变化：TROPICAL-ACS 子研究的预先指定。

Thromb Haemost. 2019 Apr;119(4):660-667. doi: 10.1055/s-0038-1677549. Epub 2019 Jan 29.

Genotype-Phenotype Association and Impact on Outcomes following Guided De-Escalation of Anti-Platelet Treatment in Acute Coronary Syndrome Patients: The TROPICAL-ACS Genotyping Substudy.基因型-表型相关性及其对急性冠状动脉综合征患者抗血小板治疗降级指导后的结局影响：TROPICAL-ACS 基因分型子研究。

Thromb Haemost. 2018 Sep;118(9):1656-1667. doi: 10.1055/s-0038-1667337. Epub 2018 Aug 13.

Platelet reactivity and clinical outcomes in acute coronary syndrome patients treated with prasugrel and clopidogrel: a pre-specified exploratory analysis from the TROPICAL-ACS trial.普拉格雷和氯吡格雷治疗急性冠脉综合征患者的血小板反应性与临床结局：TROPICAL-ACS 试验的预先设定探索性分析。

Eur Heart J. 2019 Jun 21;40(24):1942-1951. doi: 10.1093/eurheartj/ehz202.

Potent effect of prasugrel on acute phase resolution of intra-stent athero-thrombotic burden after percutaneous intervention to acute coronary syndrome.普拉格雷对经皮冠状动脉介入治疗急性冠状动脉综合征后支架内动脉粥样血栓性负担急性期消退的强效作用。

J Cardiol. 2018 Nov;72(5):403-410. doi: 10.1016/j.jjcc.2018.04.004. Epub 2018 May 4.

A randomised trial on platelet function-guided de-escalation of antiplatelet treatment in ACS patients undergoing PCI. Rationale and design of the Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment for Acute Coronary Syndromes (TROPICAL-ACS) Trial.一项关于接受经皮冠状动脉介入治疗（PCI）的急性冠状动脉综合征（ACS）患者血小板功能引导下抗血小板治疗降阶梯的随机试验。急性冠状动脉综合征慢性抗血小板治疗中血小板抑制反应性测试（TROPICAL-ACS）试验的原理与设计。

Thromb Haemost. 2017 Jan 5;117(1):188-195. doi: 10.1160/TH16-07-0557. Epub 2016 Sep 22.

High Platelet Reactivity in Patients with Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention: Randomised Controlled Trial Comparing Prasugrel and Clopidogrel.接受经皮冠状动脉介入治疗的急性冠状动脉综合征患者的高血小板反应性：比较普拉格雷和氯吡格雷的随机对照试验

PLoS One. 2015 Aug 28;10(8):e0135037. doi: 10.1371/journal.pone.0135037. eCollection 2015.

Prasugrel hydrochloride for the treatment of acute coronary syndrome patients.盐酸普拉格雷用于治疗急性冠脉综合征患者。

Expert Rev Cardiovasc Ther. 2016 Nov;14(11):1215-1226. doi: 10.1080/14779072.2016.1245145.

Platelet inhibition after loading dose of prasugrel in patients with ST-elevation and non-ST-elevation acute coronary syndrome.普拉格雷负荷剂量对ST段抬高型和非ST段抬高型急性冠脉综合征患者血小板的抑制作用

Cardiovasc Interv Ther. 2018 Jul;33(3):239-246. doi: 10.1007/s12928-017-0475-8. Epub 2017 Jun 12.

Vitamin D levels and platelet reactivity in diabetic patients receiving dual antiplatelet therapy.糖尿病患者接受双联抗血小板治疗时的维生素 D 水平和血小板反应性。

Vascul Pharmacol. 2019 Sep;120:106564. doi: 10.1016/j.vph.2019.106564. Epub 2019 Jun 7.

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A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences.血小板分子与功能研究指南：连接基础科学与临床科学

Nat Cardiovasc Res. 2022 Mar;1(3):223-237. doi: 10.1038/s44161-022-00021-z. Epub 2022 Mar 3.

Platelet in thrombo-inflammation: Unraveling new therapeutic targets.血小板在血栓炎症中的作用：揭示新的治疗靶点。

Front Immunol. 2022 Nov 14;13:1039843. doi: 10.3389/fimmu.2022.1039843. eCollection 2022.

Insights Into Platelet-Derived MicroRNAs in Cardiovascular and Oncologic Diseases: Potential Predictor and Therapeutic Target.心血管疾病和肿瘤疾病中血小板衍生微小RNA的见解：潜在的预测指标和治疗靶点

Front Cardiovasc Med. 2022 Jun 9;9:879351. doi: 10.3389/fcvm.2022.879351. eCollection 2022.

Mechanism and Potential Target of Blood-Activating Chinese Botanical Drugs Combined With Anti-Platelet Drugs: Prevention and Treatment of Atherosclerotic Cardiovascular Diseases.活血化瘀类中药联合抗血小板药物防治动脉粥样硬化性心血管疾病的作用机制及潜在靶点

Front Pharmacol. 2022 Jun 3;13:811422. doi: 10.3389/fphar.2022.811422. eCollection 2022.

Dysregulation in the Expression of Platelet Surface Receptors in Acute Coronary Syndrome Patients-Emphasis on P2Y12.急性冠状动脉综合征患者血小板表面受体表达失调——以P2Y12为重点

Biology (Basel). 2022 Apr 22;11(5):644. doi: 10.3390/biology11050644.

Circulating and Platelet MicroRNAs in Cardiovascular Risk Assessment and Antiplatelet Therapy Monitoring.循环及血小板中的微小RNA在心血管风险评估和抗血小板治疗监测中的作用

J Clin Med. 2022 Mar 22;11(7):1763. doi: 10.3390/jcm11071763.

Factors Associated with Platelet Activation-Recent Pharmaceutical Approaches.与血小板激活相关的因素——近期药物研发方法。

Int J Mol Sci. 2022 Mar 18;23(6):3301. doi: 10.3390/ijms23063301.

MicroRNA as Potential Biomarkers of Platelet Function on Antiplatelet Therapy: A Review.微小RNA作为抗血小板治疗中血小板功能的潜在生物标志物：综述

Front Physiol. 2021 Apr 15;12:652579. doi: 10.3389/fphys.2021.652579. eCollection 2021.

Methods to Investigate miRNA Function: Focus on Platelet Reactivity.研究 miRNA 功能的方法：聚焦于血小板反应。

Thromb Haemost. 2021 Apr;121(4):409-421. doi: 10.1055/s-0040-1718730. Epub 2020 Oct 29.

Revisiting Platelets and Toll-Like Receptors (TLRs): At the Interface of Vascular Immunity and Thrombosis.重新审视血小板和 Toll 样受体 (TLRs)：血管免疫与血栓形成的交汇点。

Int J Mol Sci. 2020 Aug 26;21(17):6150. doi: 10.3390/ijms21176150.

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Platelet-derived miRNAs as determinants of the antiplatelet response in clopidogrel-treated patients with ACS.

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