Ozkaynak M F, Scribano P, Gomperts E, Izadi P, Millin R, Isaacs H, Ettinger L J
Division of Hematology-Oncology, Children's Hospital, Los Angeles, CA 90027.
Am J Hematol. 1988 Nov;29(3):144-7. doi: 10.1002/ajh.2830290305.
Bone marrow cellularity estimated by biopsy was compared to the cellularity of the aspirate particle smear and the volumetric method in two groups of children. In the first group, 101 consecutive bone marrow biopsies and aspirates were evaluated from patients with various diagnoses. In the second group, 20 patients with acute nonlymphoblastic leukemia were studied with 80 biopsies and aspirates at diagnosis and following chemotherapy. A wide discrepancy was noted between bone marrow cellularity confirmed by biopsy vs. the particle smear or the volumetric method in both groups. Neither the volumetric nor the particle method provides a good correlation of bone marrow cellularity. We also compared the volumetric method with that of the biopsy to evaluate the efficacy of the former method in detecting bone marrow infiltration by solid tumors. The volumetric method is an accurate modality of identifying solid tumor infiltration in the bone marrow.
通过活检估计的两组儿童骨髓细胞密度与抽吸颗粒涂片及容积法的细胞密度进行了比较。在第一组中，对患有各种诊断的患者进行了101次连续的骨髓活检和抽吸评估。在第二组中，对20例急性非淋巴细胞白血病患者在诊断时及化疗后进行了80次活检和抽吸研究。两组中，活检证实的骨髓细胞密度与颗粒涂片或容积法之间均存在较大差异。容积法和颗粒法均未与骨髓细胞密度呈现良好的相关性。我们还将容积法与活检法进行比较，以评估前一种方法检测实体瘤骨髓浸润的效能。容积法是识别骨髓中实体瘤浸润的一种准确方法。
