Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Beijing, China.
Int J Biol Sci. 2021 Oct 3;17(15):4154-4164. doi: 10.7150/ijbs.65066. eCollection 2021.
Gastroesophageal reflux disease (GERD) is a common clinical disease associated with upper gastrointestinal motility disorders. Recently, with improvements in living standards and changes in lifestyle and dietary habits, the incidence of GERD has been increasing yearly. However, the mechanism of GERD has not been fully elucidated due to its complex pathogenesis, and this had led to unsatisfactory therapeutic outcomes. Currently, the occurrence and development of GERD involve multiple factors. Its pathogenesis is mainly thought to be related to factors, such as lower esophageal sphincter pressure, transient lower esophageal sphincter relaxation, crural diaphragmatic dysfunction, hiatus hernia, and impaired esophageal clearance. Therefore, explaining the pathogenesis of GERD more clearly and systematically, exploring potential and effective therapeutic targets, and choosing the best treatment methods have gradually become the focus of scholars' attention. Herein, we reviewed current advancements in the dynamic mechanism of GERD to better counsel patients on possible treatment options.
胃食管反流病（GERD）是一种常见的与上消化道动力障碍相关的临床疾病。近年来，随着生活水平的提高以及生活方式和饮食习惯的改变，GERD 的发病率呈逐年上升趋势。但由于其发病机制复杂，目前 GERD 的发病机制尚未完全阐明，这导致治疗效果不尽人意。目前，GERD 的发生和发展涉及多种因素。其发病机制主要与食管下括约肌压力、瞬时食管下括约肌松弛、膈脚功能障碍、裂孔疝和食管清除功能受损等因素有关。因此，更清晰、系统地阐释 GERD 的发病机制，探索潜在的、有效的治疗靶点，选择最佳的治疗方法逐渐成为学者们关注的焦点。本文就 GERD 的动力机制的研究进展进行综述，以期为患者提供更多可能的治疗选择。
