Department of Immunology and Allergology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
J Interferon Cytokine Res. 2020 Mar;40(3):125-130. doi: 10.1089/jir.2019.0094. Epub 2019 Dec 31.
The immune system plays an important role in the pathogenesis of many disorders, including allergic airway diseases. There are studies suggesting that interleukin (IL)-22 can be important in the development of these diseases. However, it is not known if this cytokine acts as proinflammatory or anti-inflammatory agent. This systematic review aimed to analyze level and role of IL-22 in patients with allergic airway diseases in comparison with healthy individuals. Systematic review included only observational studies with patients having allergic rhinitis and/or allergic asthma. The primary outcome measure was IL-22 level in patients with allergic asthma and/or allergic rhinitis. A total of 95 articles were found. Overall, 6 articles were included in systematic review. Five of these studies showed that IL-22 was increased in patients with allergic airway diseases compared with control group. Majority of studies revealed relation between IL-22 level and severity of allergic asthma and allergic rhinitis. Some studies showed positive relation between IL-22 level and total immunoglobulin E (IgE), specific IgE, and eosinophil count in nasal mucosa. IL-22 level is increased in children and adults with allergic airway diseases and is likely to be associated with proinflammatory features.
免疫系统在许多疾病的发病机制中起着重要作用，包括过敏性气道疾病。有研究表明白细胞介素（IL）-22 在这些疾病的发展中可能很重要。然而，尚不清楚这种细胞因子是作为促炎还是抗炎剂发挥作用。本系统评价旨在分析过敏性气道疾病患者与健康个体相比，IL-22 的水平和作用。系统评价仅包括观察性研究，研究对象为过敏性鼻炎和/或过敏性哮喘患者。主要结局指标是过敏性哮喘和/或过敏性鼻炎患者的 IL-22 水平。共发现 95 篇文章。总体而言，有 6 篇文章被纳入系统评价。其中 5 项研究表明，与对照组相比，过敏性气道疾病患者的 IL-22 水平升高。大多数研究表明，IL-22 水平与过敏性哮喘和过敏性鼻炎的严重程度之间存在关联。一些研究表明，IL-22 水平与血清总免疫球蛋白 E（IgE）、特异性 IgE 和鼻黏膜嗜酸性粒细胞计数之间存在正相关。过敏性气道疾病患儿和成人的 IL-22 水平升高，可能与促炎特征有关。
