白细胞介素-22 在尘螨引起的持续性过敏性气道疾病中的作用：一项初步研究。
Role of IL-22 in persistent allergic airway diseases caused by house dust mite: a pilot study.
机构信息
Department of Immunology and Allergology, Lithuanian University of Health Sciences, Eiveniu str. 2, 50009, Kaunas, Lithuania.
出版信息
BMC Pulm Med. 2021 Jan 21;21(1):36. doi: 10.1186/s12890-021-01410-z.
BACKGROUND
Persistent allergic airway diseases cause a great burden worldwide. Their pathogenesis is not clear enough. There is evidence that one of the recently described cytokine interleukin (IL) 22 may be involved in the pathogenesis of these diseases. Scientists argue if this cytokine acts as proinflammatory or anti-inflammatory agent. The aim of this study was to investigate IL-22 level in patients with persistent allergic airway diseases caused by house dust mite (HDM) in comparison with healthy individuals and to evaluate its relationship with IL-13 and IL-10 level, symptoms score and quality of life.
METHODS
Patients with persistent allergic rhinitis caused by HDM and having symptoms for at least 2 years with or without allergic asthma were involved into the study. Measurements of IL-22, IL-13 and IL-10 and in serum and nasal lavage was performed by ELISA. Questionnaires assessing symptoms severity and quality of life were used.
RESULTS
A tendency was observed that IL-22 in serum and nasal lavage was higher in patients with allergic airway diseases compared to control group (14.86 pg/ml vs. 7.04 pg/ml and 2.67 pg/ml vs. 1.28 pg/ml, respectively). Positive statistically significant correlation was estimated between serum IL-22 and serum IL-10 (rs = 0.57, p < 0.01) and IL-13 (rs = 0.44, p < 0.05) level. Moreover, positive significant correlation was found between IL-22 in nasal lavage and IL-10 in nasal lavage (rs = 0.37, p < 0.05). There was a negative statistically significant correlation between serum IL-22 and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) (rs = - 0.42, p < 0.05).
CONCLUSION
Our study showed a possible anti-inflammatory effect of IL-22 in patients with persistent allergic airway diseases caused by HDM.
背景
持续性过敏性气道疾病在全球范围内造成了巨大负担。其发病机制尚不清楚。有证据表明，最近描述的细胞因子白细胞介素（IL）22 之一可能参与这些疾病的发病机制。科学家们争论这种细胞因子是作为促炎还是抗炎剂。本研究旨在调查由屋尘螨（HDM）引起的持续性过敏性气道疾病患者的 IL-22 水平，并与健康个体进行比较，并评估其与 IL-13 和 IL-10 水平、症状评分和生活质量的关系。
方法
本研究纳入了由 HDM 引起的持续性过敏性鼻炎且至少 2 年有症状的患者，无论是否伴有过敏性哮喘。通过 ELISA 测定血清和鼻灌洗液中的 IL-22、IL-13 和 IL-10。使用评估症状严重程度和生活质量的问卷。
结果
观察到过敏性气道疾病患者的血清和鼻灌洗液中的 IL-22 水平较对照组升高（分别为 14.86 pg/ml 比 7.04 pg/ml 和 2.67 pg/ml 比 1.28 pg/ml）。血清 IL-22 与血清 IL-10（rs=0.57，p<0.01）和 IL-13（rs=0.44，p<0.05）水平呈正相关。此外，鼻灌洗液中的 IL-22 与鼻灌洗液中的 IL-10 呈正相关（rs=0.37，p<0.05）。血清 IL-22 与鼻结膜炎生活质量问卷（RQLQ）呈负相关（rs=-0.42，p<0.05）。
结论
我们的研究表明，IL-22 可能在由 HDM 引起的持续性过敏性气道疾病患者中发挥抗炎作用。
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