Wang Yue, Ma Xiaoke
Electrocardiogram Room, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
Departnent of Laboratory Medicine, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264000, P.R. China.
Exp Ther Med. 2020 Jan;19(1):591-596. doi: 10.3892/etm.2019.8269. Epub 2019 Dec 2.
Relationship between changes of electrocardiogram (ECG) indexes in chronic heart failure (CHF) with arrhythmia and serum type III procollagen amino-terminal peptide (PIIINP) and brain natriuretic peptide (BNP) were evaluated. From December 2017 to December 2018, 101 patients with heart failure (HF) were collected. Among them, 48 patients with HF and slow arrhythmia were in group A, and 53 cases of HF with non-slow arrhythmia were sin group B, including 33 males and 20 females. BNP was detected by chemiluminescence and PIIINP was detected by immunoassay. The changes of ECG indexes in the two groups, the correlation between serum PIIINP and BNP and NYHA classification of cardiac function, and the correlation between ECG indexes and PIIINP and BNP were detected. ROC curve analysis of BNP and PIIINP in the diagnosis of slow HF was carried out. Serum PIIINP and BNP in group A were significantly higher than those in group B (P<0.05). The levels of PIIINP and BNP in serum of NYHA patients with different cardiac functions, and those in serum of patients with class III were significantly higher than those of group II (P<0.05), while significantly lower than those of group IV (P<0.05). The heart rate and Q-T interval in group A were significantly higher than those in group B (P<0.05). The P-R interval and QES wave group in group A were significantly lower than those in group B (P<0.05). BNP had a positive correlation with Hr and G-T, and was negatively correlated with P-R and QRS; PIIINP was positively correlated with Hr and G-T, and had a negative correlation with P-R, QRS and BNP; PIIINP had positive correlation with NYHA; ECG indexes were correlated with BNP and PIIINP, and had diagnostic value for CHF. Using ECG indexes to predict BNP and PIIINP levels was conducive to the diagnosis of CHF.
评估慢性心力衰竭（CHF）合并心律失常患者心电图（ECG）指标变化与血清Ⅲ型前胶原氨基端肽（PIIINP）和脑钠肽（BNP）之间的关系。2017年12月至2018年12月，收集101例心力衰竭（HF）患者。其中，48例HF合并缓慢心律失常患者为A组，53例HF合并非缓慢心律失常患者为B组，包括男性33例，女性20例。采用化学发光法检测BNP，免疫分析法检测PIIINP。检测两组ECG指标变化、血清PIIINP和BNP与心功能NYHA分级的相关性以及ECG指标与PIIINP和BNP的相关性。对BNP和PIIINP诊断缓慢型HF进行ROC曲线分析。A组血清PIIINP和BNP明显高于B组（P<0.05）。不同心功能NYHA患者血清PIIINP和BNP水平，Ⅲ级患者血清PIIINP和BNP水平明显高于Ⅱ级患者（P<0.05），但明显低于Ⅳ级患者（P<0.05）。A组心率和Q-T间期明显高于B组（P<0.05）。A组P-R间期和QES波群明显低于B组（P<0.05）。BNP与心率（Hr）和G-T呈正相关，与P-R和QRS呈负相关；PIIINP与Hr和G-T呈正相关，与P-R、QRS和BNP呈负相关；PIIINP与NYHA呈正相关；ECG指标与BNP和PIIINP相关，对CHF有诊断价值。利用ECG指标预测BNP和PIIINP水平有助于CHF的诊断。
