Biomedical Research Institute, Jeonbuk National University Medical School and Hospital, Jeonju, South Korea.
Department of Neurology and Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea.
J Clin Sleep Med. 2023 Sep 1;19(9):1615-1623. doi: 10.5664/jcsm.10596.
Chronic intermittent hypoxia due to obstructive sleep apnea (OSA) causes oxidative stress, which may contribute to the pathophysiology of Parkinson's disease (PD). However, the bidirectional relationship between PD and OSA has not been satisfactorily established. The objective of this study was to try to estimate whether there is a bidirectional relationship between PD and OSA through a retrospective cohort study in the South Korean population.
This study used data from the Korean National Health Information Database of the National Health Insurance Service, which contains data from 3.5 million individuals evenly distributed. In study 1, patients with OSA were matched in a 1:2 ratio with non-OSA controls. In study 2, patients with PD were matched in a 1:2 ratio with non-PD controls. A stratified Cox proportional hazards model was used to calculate hazard ratios.
In study 1, which included 6,396 patients with OSA and 12,792 non-OSA controls, the incidence of PD per 10,000 person-years was 11.59 in the OSA group and 8.46 in the non-OSA group. The OSA group demonstrated a 1.54-fold higher incidence of PD than the non-OSA group (95% confidence interval, 1.14-2.07; < .05). In study 2, which included 3,427 patients with PD and 6,854 non-PD controls, the incidence of OSA per 10,000 person-years was 14.97 in the PD group and 7.72 in the non-PD group. The PD group demonstrated a 1.92-fold higher incidence of OSA than the non-PD group (95% confidence interval, 1.32-2.78; < .05).
This study supports a possible bidirectional relationship between PD and OSA.
Jeon S-H, Hwang YS, Oh S-Y, et al. Bidirectional association between Parkinson's disease and obstructive sleep apnea: a cohort study. . 2023;19(9):1615-1623.
阻塞性睡眠呼吸暂停（OSA）引起的慢性间歇性低氧会导致氧化应激，这可能是帕金森病（PD）病理生理学的一个致病因素。然而，PD 和 OSA 之间的双向关系尚未得到满意的确立。本研究旨在通过在韩国人群中进行回顾性队列研究，尝试估计 PD 和 OSA 之间是否存在双向关系。
本研究使用了韩国国家健康保险服务的韩国国家健康信息数据库的数据，该数据库包含了 350 万人的均匀分布数据。在研究 1 中，将 OSA 患者按照 1:2 的比例与非 OSA 对照组进行匹配。在研究 2 中，将 PD 患者按照 1:2 的比例与非 PD 对照组进行匹配。使用分层 Cox 比例风险模型计算风险比。
在包括 6396 例 OSA 患者和 12792 例非 OSA 对照组的研究 1 中，每 10000 人年中 PD 的发病率在 OSA 组为 11.59，在非 OSA 组为 8.46。OSA 组的 PD 发病率比非 OSA 组高 1.54 倍（95%置信区间，1.14-2.07；<.05）。在包括 3427 例 PD 患者和 6854 例非 PD 对照组的研究 2 中，每 10000 人年中 OSA 的发病率在 PD 组为 14.97，在非 PD 组为 7.72。PD 组的 OSA 发病率比非 PD 组高 1.92 倍（95%置信区间，1.32-2.78；<.05）。
本研究支持 PD 和 OSA 之间可能存在双向关系。
