Department of Neurology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Neurol Sci. 2020 May;41(5):1125-1131. doi: 10.1007/s10072-019-04216-4. Epub 2020 Jan 2.
Adiponectin receptors are expressed in the hypothalamus, brainstem, and basal ganglia. Experimentally, adiponectin was immunopositive in the phosphorylated α-synuclein-positive Lewy bodies in the brain of individuals with Parkinson's disease (PD), and treatment with recombinant adiponectin suppressed the aggregation of α-synuclein. The close relationship between adiponectin and PD is suggested.
We assessed whether adiponectin levels may increase in patients with PD and differ in individuals with other neurodegenerative diseases. Blood samples were stored at - 70 °C. Adiponectin levels were measured using a latex turbidimetric immunoassay.
Adiponectin levels of patients with PD (p = 0.019) or PD plus multiple systemic atrophy with predominant parkinsonian features (MSA-P) (p = 0.034) increased compared with those of patients with progressive supranuclear palsy (PSP). A multivariate comparison using ANCOVA showed that the adiponectin level was significantly higher in PD plus MSA-P than in patient with PSP, which is independent of age and BMI (adjusted mean difference of 4.388 μg/ml [95% confidence interval 0.602-8.174, p = 0.024]). A significant positive correlation between adiponectin and HDL-C levels was observed in patients with PD on a single linear regression analysis (β, 0.257; p < 0.001; R = 0.271). The results were not significant in patients with MSA-P, PSP, and MSA-P plus PSP.
Adiponectin is likely to play roles in the composition of lipid rafts since the adiponectin level of each patient with alpha-synucleinopathy or PSP differed.
脂联素受体在下丘脑、脑干和基底神经节中表达。实验中，脂联素在帕金森病（PD）患者脑内磷酸化α-突触核蛋白阳性的路易小体中呈免疫阳性，重组脂联素治疗可抑制α-突触核蛋白的聚集。脂联素与 PD 之间的密切关系被提示。
我们评估了脂联素水平是否会在 PD 患者中升高，以及在其他神经退行性疾病患者中是否存在差异。将血液样本储存在-70°C。使用乳胶比浊免疫测定法测量脂联素水平。
与进展性核上性麻痹（PSP）患者相比，PD 患者（p=0.019）或 PD 合并以帕金森病为主的多系统萎缩（MSA-P）患者（p=0.034）的脂联素水平升高。使用协方差分析（ANCOVA）的多变量比较显示，PD 合并 MSA-P 患者的脂联素水平显著高于 PSP 患者，这与年龄和 BMI 无关（调整后的平均差值为 4.388μg/ml[95%置信区间 0.602-8.174，p=0.024]）。在单一线性回归分析中，PD 患者的脂联素与高密度脂蛋白胆固醇（HDL-C）水平呈显著正相关（β，0.257；p<0.001；R=0.271）。在 MSA-P、PSP 和 MSA-P 合并 PSP 患者中，结果不显著。
脂联素可能在脂筏的组成中发挥作用，因为每种α-突触核蛋白病或 PSP 患者的脂联素水平都不同。
