Baba S, Yamaguchi J, Horie M
Laboratory of Physical and Pharmaceutical Chemistry, Tokyo College of Pharmacy, Japan.
Anal Biochem. 1988 Aug 15;173(1):196-200. doi: 10.1016/0003-2697(88)90178-9.
A high-performance liquid chromatograph with a synchronized accumulating radioisotope detector was used to determine the turnover rate and pool size of tryptophan in rat. The specific radioactivity could be followed for three half-lives on the final slope of the specific radioactivity curve following intravenous administration of 15 muCi of carrier free tryptophan labeled with carbon-14. Remarkable individual differences were noted in turnover rate and in pool size among rats.
使用配备同步累积放射性同位素检测器的高效液相色谱仪来测定大鼠体内色氨酸的周转率和池大小。静脉注射15微居里无载体的碳-14标记色氨酸后，在比放射性曲线的最终斜率上，比放射性可追踪三个半衰期。大鼠之间在周转率和池大小方面存在显著的个体差异。
