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抑郁症中P300降低:来自侧翼任务的证据及其对错误相关负波(ERN)、冲突相关负波(CRN)和Pe的影响。

Reduced P300 in depression: Evidence from a flanker task and impact on ERN, CRN, and Pe.

作者信息

Klawohn Julia, Santopetro Nicholas J, Meyer Alexandria, Hajcak Greg

机构信息

Department of Psychology, Florida State University, Tallahassee, FL, USA.

Department of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.

出版信息

Psychophysiology. 2020 Apr;57(4):e13520. doi: 10.1111/psyp.13520. Epub 2020 Jan 3.

Abstract

Individuals with current depression show reduced amplitude of the P300 component of the stimulus-locked event-related potential (ERP)-an effect most often examined in oddball tasks. Although imperative stimuli in response-monitoring paradigms (e.g., the flanker task), also elicit a P300, it is unclear whether a blunted P300 can be observed in depression in these tasks. Moreover, the P300 overlaps with the correct-response negativity (CRN) and error-related negativity (ERN), and is similar to the error positivity (Pe)-response-locked ERPs frequently examined in flanker tasks. The current study examined the stimulus-locked P300 and response-monitoring ERPs on error (i.e., ERN, Pe) and correct responses (i.e., CRN) during an arrowhead flanker task in 72 individuals with a current depressive disorder and 42 never depressed healthy individuals. Consistent with findings from oddball tasks, P300 amplitude was reduced among participants with depression. Further, results indicated increased ERN and CRN, and decreased Pe, in depression. However, when the blunted P300 was included in analyses, group differences in response-monitoring ERPs were no longer evident. Accordingly, P300 amplitudes were correlated negatively with the ERN/CRN and positively with Pe in both groups. A blunted P300 in depression can be observed in speeded response tasks, and can produce apparent increases in ERN and CRN due to ERP component overlap. Further, reduced Pe in participants with depression may reflect a reduced P300 to error commission. These data highlight the central role of reduced P300 in clinical depression, and demonstrate that this effect can be observed across both stimulus- and response-locked ERPs in speeded response tasks.

摘要

当前患有抑郁症的个体,其刺激锁定事件相关电位(ERP)的P300成分波幅降低——这一效应最常在oddball任务中进行研究。尽管在反应监测范式(如侧翼任务)中的指令性刺激也会引发P300,但尚不清楚在这些任务中,抑郁症患者是否会出现P300波幅减弱的情况。此外,P300与正确反应负波(CRN)和错误相关负波(ERN)重叠,并且类似于错误正波(Pe)——侧翼任务中经常研究的反应锁定ERP。本研究在72名当前患有抑郁症的个体和42名从未患过抑郁症的健康个体中,考察了箭头侧翼任务期间刺激锁定的P300以及对错误(即ERN、Pe)和正确反应(即CRN)的反应监测ERP。与oddball任务的研究结果一致,抑郁症患者的P300波幅降低。此外,结果表明抑郁症患者的ERN和CRN增加,Pe降低。然而,当将减弱的P300纳入分析时,反应监测ERP的组间差异不再明显。因此,两组中P300波幅均与ERN/CRN呈负相关,与Pe呈正相关。在快速反应任务中可观察到抑郁症患者的P300波幅减弱,并且由于ERP成分重叠,可能导致ERN和CRN明显增加。此外,抑郁症患者Pe降低可能反映了对错误行为的P300波幅降低。这些数据突出了P300降低在临床抑郁症中的核心作用,并表明在快速反应任务中,这种效应在刺激锁定和反应锁定的ERP中均能观察到。

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