• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

癌症免疫治疗的新视角：PD-1 在髓系细胞上发挥核心作用，调控免疫检查点阻断。

A new perspective in cancer immunotherapy: PD-1 on myeloid cells takes center stage in orchestrating immune checkpoint blockade.

机构信息

Department of Medicine, University of Montreal, Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada. Email:

出版信息

Sci Immunol. 2020 Jan 3;5(43). doi: 10.1126/sciimmunol.aaz8128.

DOI:10.1126/sciimmunol.aaz8128
PMID:31901075
Abstract

PD-1 mediates antitumor immunity by regulating lineage fate commitment and function of myeloid cells (see related Research Article by Strauss .).

摘要

PD-1 通过调节髓系细胞的谱系命运决定和功能来介导抗肿瘤免疫（参见 Strauss 等人的相关研究文章）。

相似文献

1
A new perspective in cancer immunotherapy: PD-1 on myeloid cells takes center stage in orchestrating immune checkpoint blockade.癌症免疫治疗的新视角：PD-1 在髓系细胞上发挥核心作用，调控免疫检查点阻断。
Sci Immunol. 2020 Jan 3;5(43). doi: 10.1126/sciimmunol.aaz8128.
2
PD1 Blockade in Cancer: Impact on Myeloid Cells.PD-1 阻断在癌症中的作用：对髓系细胞的影响。
Trends Cancer. 2020 Jun;6(6):443-444. doi: 10.1016/j.trecan.2020.02.018. Epub 2020 Mar 13.
3
Oleuropein-driven reprogramming of the myeloid cell compartment to sensitise tumours to PD-1/PD-L1 blockade strategies.橄榄苦苷驱动髓系细胞重编程以增强肿瘤对 PD-1/PD-L1 阻断策略的敏感性。
Br J Cancer. 2024 Mar;130(5):869-879. doi: 10.1038/s41416-023-02561-y. Epub 2024 Jan 9.
4
Myeloid Resistance is not Futile: Biomarkers of Immunotherapy in Bladder Cancer.髓系耐药并非无效：膀胱癌免疫治疗的生物标志物。
Clin Cancer Res. 2021 Aug 1;27(15):4139-4141. doi: 10.1158/1078-0432.CCR-21-1011. Epub 2021 May 27.
5
Targeted deletion of PD-1 in myeloid cells induces antitumor immunity.靶向敲除髓系细胞中的 PD-1 可诱导抗肿瘤免疫。
Sci Immunol. 2020 Jan 3;5(43). doi: 10.1126/sciimmunol.aay1863.
6
LIGHT (TNFSF14) Costimulation Enhances Myeloid Cell Activation and Antitumor Immunity in the Setting of PD-1/PD-L1 and TIGIT Checkpoint Blockade.LIGHT（TNFSF14）共刺激增强了 PD-1/PD-L1 和 TIGIT 检查点阻断条件下的髓样细胞激活和抗肿瘤免疫。
J Immunol. 2022 Aug 1;209(3):510-525. doi: 10.4049/jimmunol.2101175. Epub 2022 Jul 11.
7
Recent advances in the clinical development of immune checkpoint blockade therapy.免疫检查点阻断疗法的临床开发进展。
Cell Oncol (Dordr). 2019 Oct;42(5):609-626. doi: 10.1007/s13402-019-00456-w. Epub 2019 Jun 14.
8
Functionalized biomimetic nanoparticles combining programmed death-1/programmed death-ligand 1 blockade with photothermal ablation for enhanced colorectal cancer immunotherapy.功能化仿生纳米颗粒结合程序性死亡-1/程序性死亡配体-1阻断与光热消融用于增强结直肠癌免疫治疗。
Acta Biomater. 2023 Feb;157:451-466. doi: 10.1016/j.actbio.2022.11.043. Epub 2022 Nov 25.
9
Checkpoint blockade for cancer therapy: revitalizing a suppressed immune system.癌症治疗的免疫检查点阻断：重焕受抑制免疫系统的活力。
Trends Mol Med. 2015 Aug;21(8):482-91. doi: 10.1016/j.molmed.2015.05.005. Epub 2015 Jun 16.
10
Adaptive antitumor immune response stimulated by bio-nanoparticle based vaccine and checkpoint blockade.基于生物纳米颗粒的疫苗和检查点阻断刺激的适应性抗肿瘤免疫反应。
J Exp Clin Cancer Res. 2022 Apr 8;41(1):132. doi: 10.1186/s13046-022-02307-3.

引用本文的文献

1
TGF-β1 induces PD-1 expression in macrophages through SMAD3/STAT3 cooperative signaling in chronic inflammation.TGF-β1 通过 SMAD3/STAT3 协同信号在慢性炎症中诱导巨噬细胞表达 PD-1。
JCI Insight. 2024 Mar 5;9(7):e165544. doi: 10.1172/jci.insight.165544.
2
Immunological characterization of a long-lasting response in a patient with metastatic triple-negative breast cancer treated with PD-1 and LAG-3 blockade.免疫特性分析：PD-1/LAG-3 双阻断治疗转移性三阴性乳腺癌患者的持久应答。
Sci Rep. 2024 Feb 9;14(1):3379. doi: 10.1038/s41598-024-54041-9.
3
Systemic administration of STING agonist promotes myeloid cells maturation and antitumor immunity through regulating hematopoietic stem and progenitor cell fate.
全身性给予 STING 激动剂通过调节造血干细胞和祖细胞命运促进髓系细胞成熟和抗肿瘤免疫。
Cancer Immunol Immunother. 2023 Nov;72(11):3491-3505. doi: 10.1007/s00262-023-03502-7. Epub 2023 Aug 7.
4
FARSB serves as a novel hypomethylated and immune cell infiltration related prognostic biomarker in hepatocellular carcinoma.FARSB 作为一种新型低甲基化且与免疫细胞浸润相关的肝癌预后生物标志物。
Aging (Albany NY). 2023 Apr 3;15(8):2937-2969. doi: 10.18632/aging.204619.
5
Prognostic Signature GXYLT2 Is Correlated with Immune Infiltration in Bladder Cancer.预后标志物 GXYLT2 与膀胱癌中的免疫浸润相关。
Dis Markers. 2022 Oct 10;2022:5081413. doi: 10.1155/2022/5081413. eCollection 2022.
6
Prognostic and Immunological Value of GNB4 in Gastric Cancer by Analyzing TCGA Database.基于 TCGA 数据库分析 GNB4 在胃癌中的预后和免疫价值。
Dis Markers. 2022 Jun 16;2022:7803642. doi: 10.1155/2022/7803642. eCollection 2022.
7
Pan-Cancer Analysis of Microfibrillar-Associated Protein 2 (MFAP2) Based on Bioinformatics and qPCR Verification.基于生物信息学和qPCR验证的微原纤维相关蛋白2（MFAP2）泛癌分析
J Oncol. 2022 Feb 15;2022:8423173. doi: 10.1155/2022/8423173. eCollection 2022.
8
Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy.羟氯喹（HCQ）降低了肿瘤免疫治疗中抗 PD-1 免疫检查点阻断的疗效。
PLoS One. 2021 Jun 28;16(6):e0251731. doi: 10.1371/journal.pone.0251731. eCollection 2021.
9
Marine Seagrass Extract of Suppresses Colorectal Tumor Growth, Motility and Angiogenesis by Autophagic Stress and Immunogenic Cell Death Pathways.海洋海草提取物通过自噬应激和免疫原性细胞死亡途径抑制结直肠癌的生长、运动和血管生成。
Mar Drugs. 2021 Jan 22;19(2):52. doi: 10.3390/md19020052.
10
Rethinking immune checkpoint blockade: 'Beyond the T cell'.重新思考免疫检查点阻断：“超越 T 细胞”。
J Immunother Cancer. 2021 Jan;9(1). doi: 10.1136/jitc-2020-001460.