Rekatsina Martina, Paladini Antonella, Piroli Alba, Zis Panagiotis, Pergolizzi Joseph V, Varrassi Giustino
Department of Anaesthesia and Pain Management, King's College Hospital, London, UK.
Department of MESVA, University of L'Aquila, 67100, L'Aquila, Italy.
Pain Ther. 2020 Jun;9(1):7-21. doi: 10.1007/s40122-019-00147-2. Epub 2020 Jan 4.
Pain management is challenging for both clinicians and patients. In fact, pain patients are frequently undertreated or even completely untreated. Optimal treatment is based on targeting the underlying mechanisms of pain and tailoring the management modality for each patient using a personalized approach. This narrative review deals with pain conditions that have a complex underlying mechanism and need an individualized and frequently multifactorial approach to pain management. The research is based on previously conducted studies, and does not contain any studies with human participants or animals performed by any of the authors. This is not an exhaustive review of the current evidence. However, it provides the clinician with a perspective on pain therapy targeting the underlying pain mechanism(s). When dealing with complex pain conditions, the prudent physician benefits from having a deep knowledge of various underlying pain mechanisms in order to provide a plan for optimal pharmacological pain relief to patients.
疼痛管理对临床医生和患者来说都具有挑战性。事实上，疼痛患者常常得不到充分治疗，甚至完全未接受治疗。最佳治疗方法是针对疼痛的潜在机制，并采用个性化方法为每位患者量身定制管理模式。本叙述性综述探讨了那些具有复杂潜在机制且需要个性化且通常是多因素疼痛管理方法的疼痛病症。该研究基于先前进行的研究，不包含任何作者进行的涉及人类参与者或动物的研究。这并非对当前证据的详尽综述。然而，它为临床医生提供了针对潜在疼痛机制进行疼痛治疗的视角。在处理复杂疼痛病症时，谨慎的医生受益于对各种潜在疼痛机制的深入了解，以便为患者提供最佳药物止痛方案。
