Innovative Centre for Flexible Devices (iFLEX), School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
J Mater Chem B. 2020 Apr 29;8(16):3341-3356. doi: 10.1039/c9tb02352f.
Biomedical devices that involved continuous and real-time health-care monitoring have drawn much attention in modern medicine, of which skin electronics and implantable devices are widely investigated. Skin electronics are characterized for their non-invasive access to the physiological signals, and implantable devices are superior at the diagnosis and therapy integration. Despite the significant progress achieved, many gaps remain to be explored to provide a more comprehensive overview of human health. As the connecting point of the outer environment and human systems, the oral cavity contains many unique biomarkers that are absent in skin or inner organs, and hence, this could become a promising alternative locus for designing health-care monitoring devices. In this review, we outline the status of the oral cavity during the communication of the environment and human systems and compare the intraoral devices with skin electronics and implantable devices from the biophysical and biochemical aspects. We further summarize the established diagnosis database and technologies that could be adopted to design intraoral biosensors. Finally, the challenges and potential opportunities for intraoral biosensors are discussed. Intraoral biosensors could become an important complement for existing biomedical devices to constitute a more reliable health-care monitoring system.
生物医学设备涉及连续和实时的医疗保健监测，在现代医学中引起了广泛关注，其中皮肤电子学和植入式设备得到了广泛研究。皮肤电子学的特点是无创获取生理信号，而植入式设备则在诊断和治疗方面具有优势。尽管已经取得了重大进展，但仍有许多空白需要探索，以提供更全面的人类健康概述。作为外部环境和人体系统的连接点，口腔包含许多在皮肤或内部器官中不存在的独特生物标志物，因此，这可能成为设计医疗保健监测设备的有前途的替代部位。在这篇综述中，我们概述了口腔在环境和人体系统交流中的状态，并从生物物理和生化方面比较了口腔内设备与皮肤电子学和植入式设备。我们进一步总结了已建立的诊断数据库和可用于设计口腔内生物传感器的技术。最后，讨论了口腔内生物传感器的挑战和潜在机遇。口腔内生物传感器可能成为现有生物医学设备的重要补充，以构成更可靠的医疗保健监测系统。
