3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal.
ICVS/3B's-PT Government Associate Laboratory, 4710-057 Braga, Portugal.
Biosensors (Basel). 2020 Jul 21;10(7):79. doi: 10.3390/bios10070079.
Biosensors devices have attracted the attention of many researchers across the world. They have the capability to solve a large number of analytical problems and challenges. They are future ubiquitous devices for disease diagnosis, monitoring, treatment and health management. This review presents an overview of the biosensors field, highlighting the current research and development of bio-integrated and implanted biosensors. These devices are micro- and nano-fabricated, according to numerous techniques that are adapted in order to offer a suitable mechanical match of the biosensor to the surrounding tissue, and therefore decrease the body's biological response. For this, most of the skin-integrated and implanted biosensors use a polymer layer as a versatile and flexible structural support, combined with a functional/active material, to generate, transmit and process the obtained signal. A few challenging issues of implantable biosensor devices, as well as strategies to overcome them, are also discussed in this review, including biological response, power supply, and data communication.
生物传感器设备引起了世界各地许多研究人员的关注。它们有能力解决大量的分析问题和挑战。它们是未来用于疾病诊断、监测、治疗和健康管理的无处不在的设备。本综述介绍了生物传感器领域的概况，重点介绍了生物集成和植入式生物传感器的当前研究和开发。这些设备是根据多种技术进行微纳加工制造的，这些技术被用来提供生物传感器与周围组织的合适机械匹配，从而降低生物体的生物反应。为此，大多数皮肤集成和植入式生物传感器使用聚合物层作为通用的和灵活的结构支撑，结合功能/活性材料，以产生、传输和处理获得的信号。本综述还讨论了植入式生物传感器设备的一些挑战性问题以及克服这些问题的策略，包括生物反应、电源和数据通信。
