Departamento de Fisioterapia, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, Spain.
Motion in Brains Research Group, Institute of Neuroscience and Sciences of the Movement (INCIMOV), Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, Spain.
Scand J Med Sci Sports. 2020 Jun;30(6):965-982. doi: 10.1111/sms.13625. Epub 2020 Jan 25.
To assess the effects of aerobic exercise (AE) on patients with migraine in terms of pain intensity, frequency and duration of migraine, and quality of life.
A systematic review and meta-analysis of randomized controlled trials were conducted. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated for relevant outcomes and were pooled in a meta-analysis using the random-effects model.
A total of 10 articles from 1950 to 2019 were included, involving 508 patients. The meta-analysis showed statistically significant differences in the decrease in pain intensity (five studies, n = 166; SMD = 1.25; 95% CI 0.47-2.04), frequency (six studies, n = 214; SMD = 0.76; 95% CI 0.32-1.2) and duration of migraine (four studies, n = 106; SMD = 0.41; 95% CI 0.03-0.8), in the short-term. In addition, the meta-analysis showed statistically significant differences in the increase in quality of life (four studies, n = 150; SMD = 2.7; 95% CI 1.17-4.24), even though the Egger's test suggested significant evidence of publication bias for the analysis of quality of life (intercept = 5.81; t = 6.97; P = .02).
There is low- and moderate-quality evidence that in patients with migraine AE can decrease the pain intensity, frequency and duration of migraine and can also increase quality of life.
评估有氧运动（AE）对偏头痛患者疼痛强度、偏头痛发作频率和持续时间以及生活质量的影响。
对随机对照试验进行系统评价和荟萃分析。使用随机效应模型对相关结局的标准化均数差值（SMD）和 95%置信区间（CI）进行汇总分析。
共纳入 1950 年至 2019 年的 10 项研究，涉及 508 例患者。荟萃分析显示，在疼痛强度（5 项研究，n=166；SMD=1.25；95%CI 0.47-2.04）、发作频率（6 项研究，n=214；SMD=0.76；95%CI 0.32-1.2）和偏头痛持续时间（4 项研究，n=106；SMD=0.41；95%CI 0.03-0.8）方面，AE 在短期治疗中可使疼痛减轻，差异有统计学意义。此外，荟萃分析还显示，AE 可提高生活质量，差异有统计学意义（4 项研究，n=150；SMD=2.7；95%CI 1.17-4.24），但 Egger 检验提示分析生活质量时存在显著的发表偏倚证据（截距=5.81；t=6.97；P=0.02）。
低质量和中等质量证据表明，AE 可降低偏头痛患者的疼痛强度、发作频率和持续时间，提高生活质量。
