Das M, Ray P K
Industrial Toxicology Research Centre, Lucknow, India.
Biochem Int. 1988 Aug;17(2):203-9.
The effect of quercetin on iron-catalyzed hepatic microsomal lipid peroxidation was investigated. Quercetin was shown to be a potent inhibitor of iron-induced lipid peroxidation with a I50 of 0.2 mM. The inhibitory effects of quercetin were dependent on incubation time, protein concentration and iron content in the incubation mixture. Since quercetin does not interact with malonyl-aldehyde it can be concluded that the inhibition of iron induced lipid peroxidation is due to lipid antioxidant property and this may serve as a model for the study by which "free" iron may initiate peroxidation in vivo.
研究了槲皮素对铁催化的肝微粒体脂质过氧化的影响。结果表明，槲皮素是铁诱导脂质过氧化的有效抑制剂，其半数抑制浓度（I50）为0.2 mM。槲皮素的抑制作用取决于孵育时间、蛋白质浓度和孵育混合物中的铁含量。由于槲皮素不与丙二醛相互作用，因此可以得出结论，铁诱导脂质过氧化的抑制作用是由于脂质抗氧化特性，这可能为研究“游离”铁在体内引发过氧化的机制提供一个模型。
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