Tan Zhen, Xu Jin, Zhang Bo, Shi Si, Yu Xianjun, Liang Chen
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 270 Dong'An Road, Shanghai, 200032, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Cell Mol Life Sci. 2020 Aug;77(16):3077-3083. doi: 10.1007/s00018-019-03444-3. Epub 2020 Jan 6.
Pancreatic cancer (PC) remains one of the most extremely lethal malignancies worldwide due to late diagnosis and early metastasis, with a 1-year overall survival rate of approximately 20%. The hypoxic microenvironment, induced by intratumoral hypoxia, promotes tumor invasion and progression, leading to chemotherapy or radiotherapy resistance and eventual mortality after treatment of PC. However, the role of the hypoxic microenvironment in PC is complicated and requires further investigation. In this article, we review recent advances regarding the regulation of malignant behaviors in PC, which provide insight into the potential of hypoxic microenvironment activation therapy for the therapeutic agents.
由于诊断较晚和早期转移,胰腺癌(PC)仍然是全球最致命的恶性肿瘤之一,其1年总生存率约为20%。肿瘤内缺氧诱导的缺氧微环境促进肿瘤侵袭和进展,导致化疗或放疗耐药,并最终导致胰腺癌治疗后的死亡。然而,缺氧微环境在胰腺癌中的作用较为复杂,需要进一步研究。在本文中,我们综述了胰腺癌恶性行为调控方面的最新进展,这些进展为缺氧微环境激活疗法作为治疗药物的潜力提供了见解。